Lower BDNF levels observed in bipolar disorder patients may lead to reduced EGR3 levels. A dysfunctional pathway impairs several biological functions, including abnormal structural brain changes and cognitive and functional decline (known as neuroprogression). Disrupted neural circuits may explain the impaired neuroplasticity and resilience, increasing vulnerability to stress and mood episodes, all well-known characteristics of BD.

A new article reveals a novel potential drug target for bipolar disorder and offers new insights into the underlying biology of this lifelong and devastating mental illness. Bipolar Disorder (BD) is a multifactorial brain disorder in which patients experience radical shifts in mood and undergo periods of depression followed by periods of mania...

This artist’s impression shows several of the planets orbiting the ultra-cool red dwarf star TRAPPIST-1. New observations, when combined with very sophisticated analysis, have now yielded good estimates of the densities of all seven of the Earth-sized planets and suggest that they are rich in volatile materials, probably water. Credit: ESO/M. Kornmesser

A new study has found that planets orbiting the star TRAPPIST-1 are made mostly of rock, and some could hold more H2O than Earth. The planets’ densities suggest that some of them could have up to 5% of their mass in the form of water. The hotter planets closest to their parent star are likely to have dense steamy atmospheres and the more distant ones probably have icy surfaces...

This artist’s concept shows what the TRAPPIST-1 planetary system may look like, based on available data about the planets’ diameters, masses, and distances from the host star, as of February 2018. Credit: NASA, JPL/Caltech, and R. Hurt and T. Pyle (IPAC)

Astronomers using Hubble have conducted the first spectroscopic survey of the Earth-sized planets (d, e, f, and g) within the habitable zone around the nearby star TRAPPIST-1. This study is a follow-up to Hubble observations made in May 2016 of the atmospheres of the inner TRAPPIST-1 planets b and c. Hubble reveals that at least 3 of the exoplanets (d, e, and f) do not seem to contain puffy, hydrogen-rich atmospheres similar to gaseous planets such as Neptune...

“Green” sunscreens could soon be easier to make, thanks to a new laboratory method for the production of a key ingredient. Credit: Estrada Anton/Shutterstock.com

Although it’s been a tough winter for many people in the U.S., summer is coming. And that means backyard barbeques, fun on the beach and, of course, slathering on sunscreen. But one particular environmentally friendly sunscreen ingredient has been difficult to obtain – shinorine, could only be harvested from nature. Scientists now report in ACS Synthetic Biology the laboratory production of that compound.

Sunscreen is key to protecting the skin from carcinogenic UV radiation. However, some synthetic sunscreen components can accumulate in aquatic environments and potentially cause harm by acting as hormone disruptors...