Genome wide association study of Epigenetic Aging rates in blood reveals a Critical Role for TERT

The structure of human telomerase reverse transcriptase (hTERT). Human TERT contains four key domains: the telomerase essential N-terminal (TEN) domain; the TERT RNA binding (TRB) domain; the reverse transcriptase (RT) domain and the C-terminal extension (CTE) domain.

The structure of human telomerase reverse transcriptase (hTERT). Human TERT contains four key domains: the telomerase essential N-terminal (TEN) domain; the TERT RNA binding (TRB) domain; the reverse transcriptase (RT) domain and the C-terminal extension (CTE) domain.

Researchers from several institutions, including, UCLA, Boston University, Stanford University and the Institute for Aging Research at Hebrew SeniorLife, analyzed blood samples from nearly 10,000 people to find that genetic markers in the gene responsible for keeping telomeres (tips of chromosomes) youthfully longer, did not translate into a younger biologic age as measured by changes in proteins coating the DNA.

DNA methylation age is a biomarker of chronological age and predicts lifespan, but its underlying molecular mechan...

Read More

Scientists discover ‘Chiral Phonons’ – Atomic Rotations in a 2D Semiconductor Crystal

This diagram maps out atomic motion in separate phonon modes. At left ("LO" represents a longitudinal optical mode), selenium atoms exhibit a clockwise rotation while tungsten atoms stand still. At right ("LA" represents a longitudinal acoustic mode), tungsten atoms exhibit a clockwise rotation while selenium atoms rotate in a counterclockwise direction. Credit: Hanyu Zhu, et al.

This diagram maps out atomic motion in separate phonon modes. At left (“LO” represents a longitudinal optical mode), selenium atoms exhibit a clockwise rotation while tungsten atoms stand still. At right (“LA” represents a longitudinal acoustic mode), tungsten atoms exhibit a clockwise rotation while selenium atoms rotate in a counterclockwise direction. Credit: Hanyu Zhu, et al.

Experiments confirm the first chiral phonon that could enable exotic forms of electronics. Berkeley Lab has found the first evidence that a shaking motion in the structure of an atomically thin (2D) material possesses a naturally occurring circular rotation...

Read More

Bacteria play critical role in Driving Colon Cancers

Bacteria play a critical role in the development of colon cancer, new research suggests. Credit: Elizabeth Cook

Bacteria play a critical role in the development of colon cancer, new research suggests. Credit: Elizabeth Cook

Patients with an inherited form of colon cancer harbor two bacterial species that collaborate to encourage development of the disease, and the same species have been found in people who develop a sporadic form of colon cancer, a study led by a Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy research team finds. A second study in mice published concurrently by the same researchers shows a possible mechanism behind how one of these species spurs a specific type of immune response, promoting – instead of inhibiting – the formation of malignant tumors...

Read More

Astrophysicists discover Planets in Extragalactic Galaxies using Microlensing

Image of the gravitational lens RX J1131-1231 galaxy with the lens galaxy at the center and four lensed background quasars. It is estimated that there are trillions of planets in the center elliptical galaxy in this image. Credit: University of Oklahoma

Image of the gravitational lens RX J1131-1231 galaxy with the lens galaxy at the center and four lensed background quasars. It is estimated that there are trillions of planets in the center elliptical galaxy in this image. Credit: University of Oklahoma

A University of Oklahoma astrophysics team has discovered for the first time a population of planets beyond the Milky Way galaxy. Using microlensing – an astronomical phenomenon and the only known method capable of discovering planets at truly great distances from the Earth among other detection techniques – OU researchers were able to detect objects in extragalactic galaxies that range from the mass of the Moon to the mass of Jupiter.

Xinyu Dai, professor in the Homer L...

Read More