CRISPR Genetic Editing takes another big step forward, targeting RNA

CasRx (magenta) targeting RNA in the nucleus of human cells (gray). Credit: Salk Institute

CasRx (magenta) targeting RNA in the nucleus of human cells (gray). Credit: Salk Institute

Most people have heard of the CRISPR/Cas9 gene-editing technology, which acts as targeted molecular scissors to cut and replace disease-causing genes with healthy ones. But DNA is only part of the story; many genetic diseases are caused by problems with RNA, a working copy of DNA that is translated into proteins. Now, Salk Institute scientists have created a new tool that targets not DNA, but RNA, and used it to correct a protein imbalance in cells from a dementia patient, restoring them to healthy levels...

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PENTAERYTHRITOL

PENTAERYTHRITOL

~ also known as Pentek; 115-77-5; 2,2-bis(hydroxymethyl)propane-1,3-diol; Tetramethylolmethane; Monopentaerythritol; etc. is classified as a member of the Primary alcohols. Global pentaerythritol market is expected to reach USD 1.85 billion by 2020 and it is expected to grow at an estimated CAGR of 5.6%. Chemical structure: C(CH2OH)4 or C5H12O4. It is a polyol with the neopentane backbone and one hydroxyl group in each of the four terminal carbons.

Properties: Pentaerythritol is an organic compound. It exists as a white, crystalline solid. It sinks and mixes slowly with water.

Production:  It may be prepared via a base-catalyzed poly-condensation reaction between acetaldehyde and 3 equivalents of formaldehyde...

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METHYL ACETATE

METHYL ACETATE

~ also known as Tereton; 79-20-9; Devoton; Acetic acid methyl ester; Methyl ethanoate; etc. belongs to the family of Carboxylic Acid Esters. The global market for methyl acetate and other exempt solvents was valued at over USD 1.54 billion in 2016. It is expected to reach USD 2.42 billion in 2022 and grow at a CAGR of slightly above 3.0% between 2017 and 2022.
Chemical structure: C3H6O2 or CH3COOCH3. It is a carboxylate ester whose formula can also be written as MeOAc.
Properties: Methyl acetate is a non-polar (lipophilic) to weakly polar (hydrophilic) aprotic solvent. Methyl acetate has a solubility of 25% in water at room temperature. At elevated temperature, its solubility in water is much higher...
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BENZYL ALCOHOL

BENZYL ALCOHOL

~ also known as Phenylmethanol; Benzoyl alcohol; Benzenemethanol; 100-51-6; Phenylcarbinol; etc. is produced naturally by many plants and is commonly found in fruits and teas. It is also found in a variety of essential oils including jasmine, hyacinth, ylang-ylang, and in castoreum from the castor sacs of beavers. Due to increasing demand from end-use industries, the global Benzyl Alcohol Market is expected to reach US$282.3 million by 2025, expanding at a CAGR of 4.2% during the forecast period 2017 – 2025.
Chemical structure: Benzyl alcohol is an aromatic alcohol with the formula C7H8O or C6H5CH2OH. The benzyl group is often abbreviated “Bn”, thus benzyl alcohol is denoted as BnOH.
Properties: Benzyl alcohol is a colorless liquid with a mild pleasant aromatic odor...
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