This image shows the shapes made of living tissue made by the researchers. By patterning mechanically active mouse or human cells to thin layers of extracellular fibers, the researchers could create bowls, coils, and ripple shapes. Credit: Alex Hughes

Many of the complex folded shapes that form mammalian tissues can be recreated with very simple instructions, UC San Francisco bioengineers report December 28 in the journal Developmental Cell. By patterning mechanically active mouse or human cells to thin layers of extracellular matrix, ECM fibers, the researchers could create bowls, coils, and ripples out of living tissue. The cells collaborated mechanically through a web of these fibers to fold themselves up in predictable ways, mimicking natural developmental processes.

“Development is st...

OSIRIS medium-resolution spectrum of J0815+4729 (black line) and the best fit obtained with FERRE (red line). Credit: Aguado et al., 2017.

Spanish astronomers have identified a new carbon-rich ultra metal-poor unevolved star in the halo of the Milky Way galaxy. The newly found star, designated J0815+4729, could be the most iron-poor unevolved star known to date. Chemically primitive metal-poor stars are important for studying the conditions in the early universe. Thus, astronomers are interested in identifying more stars of this type and deriving their chemical abundances. Large sample of such stars could be helpful in improving our knowledge about stellar formation and evolution.

Recently, a team led by David S...

Concept illustration of microneedle device for type 2 diabetes treatment. Credit: Chen lab, NIBIB.

Researchers have devised a biochemically formulated patch of dissolvable microneedles for the treatment of type 2 diabetes. The biochemical formula of mineralized compounds in the patch responds to blood chemistry to manage glucose automatically. In a proof-of-concept study performed with mice, the researchers showed that the chemicals interact in the bloodstream to regulate blood sugar for days at a time. “This experimental approach could be a way to take advantage of the fact that persons with type 2 diabetes can still produce some insulin,” said Richard Leapman, Ph.D., NIBIB scientific director...

This is a photograph of a 3-D hydrogel construct obtained through drop-on-drop multi-material bioprintinig. Credit: Osaka University

Researchers develop a finely tuned enzyme-driven crosslinking method to glue together biological ink droplets and extend the range of cell types that can be handled by inkjet bioprinting. Such printing holds strong promise for regenerative medicine, such as in use of iPS cells. Researchers refine method of making bio-ink droplets stick to each other, enabling 3D printing of highly complex biological structures with a wide variety of cell types using inkjet printers.

Before any real applications, “bioprinting” has always faced many technical challenges...