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    Learning and Staying in Shape key to Longer Lifespan, study finds

    October 14, 2017, Categories  Health/Medical, Biology/Biotechnology

    Age-specific and sex-specific effects of the 4 GWS associations in LifeGen and the validated candidate loci. The four GWS and three suggestive replicated loci were analysed for age-specific and sex-specific effects on lifespan. a The variants at APOE and CHRNA3/5 exhibit sexually dimorphic effects on parental mortality, while all other variants exhibit more modest often non-significant sex-specific differences. b The effects of each gene on male and female lifespan were meta-analysed and studied in the cases that died aged between 40 and 75 or after 75. APOE exerts a much greater effect in the older age group, while most of the other genes exhibit the opposite effect. FOXO3 appears neutral, if not positive, in the earlier age group. c Effects on mortality were studied in both age groups for both sexes. APOE has the strongest effect on females aged 75+, CHRNA3/5 acts on males aged 40−75 and all other genes display more ambiguous trends

    Age-specific and sex-specific effects of the 4 GWS associations in LifeGen and the validated candidate loci. The four GWS and three suggestive replicated loci were analysed for age-specific and sex-specific effects on lifespan. a The variants at APOE and CHRNA3/5 exhibit sexually dimorphic effects on parental mortality, while all other variants exhibit more modest often non-significant sex-specific differences. b The effects of each gene on male and female lifespan were meta-analysed and studied in the cases that died aged between 40 and 75 or after 75. APOE exerts a much greater effect in the older age group, while most of the other genes exhibit the opposite effect. FOXO3 appears neutral, if not positive, in the earlier age group...

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    KLF-mediated lifespan extension is dependent on autophagy. Klf-3 transcript levels in wild-type animals subjected to 2 days of chronic dietary restriction (sDR, OP50 diluted to 108 cfu/ml) (a) or inhibition of TOR signaling by RNAi against let-363 (b) starting from day 1 of adulthood. All lines were raised and maintained at 20 °C. *P-value < 0.05 by Student’s T-test, N = 3 biological replicates. c qPCR analysis of a panel of autophagy-related genes in day 1 klf-3 o/e and loss of function of both klf-3 and klf-1 animals compared to wild type. Double loss of function of klf-3 and klf-1 was performed as described previously utilizing the klf-3(ok175) mutant and simultaneous RNAi feeding targeting klf-1. All lines were raised and maintained at 20 °C. *P-value < 0.05 by Student’s T-test, N = 3 biological replicates (d, representative picture). e Autophagy in klf-3 o/e animals as determined by numbers of GFP::LGG-1 punctae in seam cells (red arrow denotes GFP-positive puncta) with knockdown of bec-1 in both wild-type and klf-3 o/e animals. *P-value < 0.05, # P-value ≤ 0.1 after one-way analysis of variance followed by the Tukey’s post hoc test. N = 10–20 animals counted. (f, wild-type representative image, g, klf-3 o/e representative image) Electron microscopy images of klf-3 o/e and wild-type animals in animals aged 9 days. Arrowheads indicate sizeable (≥500 nm) autolysosomes as recognized by single-membrane limited vacuolar structures with visible mixed cytoplasmic contents. Full images reproduced in Supplementary Fig. 11, with additional images. h Lifespan analysis of wild-type and klf-3 o/e animals fed RNAi bacteria targeting bec-1 from day 1 of adulthood. All lines were raised and maintained at 20 °C. P-value < 0.05 by Mantel–Cox log-rank tests. See also Supplementary Table 6 for details of lifespan analyses and replicate experiments. All error bars represent standard error of the mean (SEM)

    KLF-mediated lifespan extension is dependent on autophagy. Klf-3 transcript levels in wild-type animals subjected to 2 days of chronic dietary restriction (sDR, OP50 diluted to 108 cfu/ml) (a) or inhibition of TOR signaling by RNAi against let-363 (b) starting from day 1 of adulthood. All lines were raised and maintained at 20 °C. *P-value < 0.05 by Student’s T-test, N = 3 biological replicates. c qPCR analysis of a panel of autophagy-related genes in day 1 klf-3 o/e and loss of function of both klf-3 and klf-1 animals compared to wild type. Double loss of function of klf-3 and klf-1 was performed as described previously utilizing the klf-3(ok175) mutant and simultaneous RNAi feeding targeting klf-1. All lines were raised and maintained at 20 °C. *P-value < 0...

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    Spin Current Detection in Quantum Materials unlocks Potential for Alternative Electronics

    October 14, 2017, Categories  Physics, Technology/Electronics

    A new microscopy method developed by an ORNL-led team has four movable probing tips, is sensitive to the spin of moving electrons and produces high-resolution results. Using this approach, they observed the spin behavior of electrons on the surface of a quantum material. Credit: Saban Hus and An-Ping Li/Oak Ridge National Laboratory, U.S. Dept. of Energy

    A new microscopy method developed by an ORNL-led team has four movable probing tips, is sensitive to the spin of moving electrons and produces high-resolution results. Using this approach, they observed the spin behavior of electrons on the surface of a quantum material. Credit: Saban Hus and An-Ping Li/Oak Ridge National Laboratory, U.S. Dept. of Energy

    A new method that precisely measures the mysterious behavior and magnetic properties of electrons flowing across the surface of quantum materials could open a path to next-generation electronics. Silicon-based semiconductors rely on the controlled electrical current responsible for powering electronics. These semiconductors can only access the electrons’ charge for energy, but electrons do more than carry a charge...

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    Astronomers find potential Solution into how Planets Form

    October 14, 2017, Categories  Astronomy/Space

    This image shows V1247 Orionis, a young, hot star surrounded by a dynamic ring of gas and dust, known as a circumstellar disc. The disc can be seen in two parts: a clearly defined central ring of matter and a more delicate crescent structure located further out. Credit: Stefan Kraus

    This image shows V1247 Orionis, a young, hot star surrounded by a dynamic ring of gas and dust, known as a circumstellar disc. The disc can be seen in two parts: a clearly defined central ring of matter and a more delicate crescent structure located further out. Credit: Stefan Kraus

    The quest to discover how planets found in the far reaches of the universe are born has taken a new, crucial twist. A new study by an international team of scientists, led by Stefan Kraus from the University of Exeter, has given a fascinating new insight into one of the most respected theories of how planets are formed. Young stars start out with a massive disk of gas and dust that over time, astronomers think, either diffuses away or coalesces into planets and asteroids.

    However, scientists are still searching...

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