Gene Therapy using ‘Junk DNA’ could Lower Risk for Heart Disease

Image of LeXis (pink dots) inside a cell. The larger blue dots marks the nuclei of liver cells.

Credit: Judy Wu / UCLA Division of Cardiology Image of LeXis (pink dots) inside a cell. The larger blue dots marks the nuclei of liver cells.

Scientists from UCLA and the Howard Hughes Medical Institute successfully used a gene that suppresses cholesterol levels as part of a treatment to reduce plaque in mice with a disorder called familial hypercholesterolemia. In a preclinical study, gene LeXis, lowered cholesterol and blockages in the arteries, and the treatment appeared to reduce the build-up of fat in liver cells. Familial hypercholesterolemia is an inherited condition characterized by extremely high levels of LDL and an increased risk of early heart disease.

The LeXis gene belongs to a unique group of genes that until recently were considered “junk DNA” because scientists believed th...

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More Solar Power thanks to Titanium

More Solar Power Thanks to Titanium - Modification of a hematite photoanode by a conformal titanium dioxide interlayer for effective charge collection

Dendritic Hematite Nanoarray Photoanode Modified with a Conformal Titanium Dioxide Interlayer for Effective Charge Collection. Angewandte Chemie International Edition, 2017; DOI: 10.1002/anie.201705772

Modification of a hematite photoanode by a conformal titanium dioxide interlayer for effective charge collection. Earth-abundant, cheap metals are promising photocatalytic electrode materials in artificial photosynthesis. The nanostructured electrode benefits from two separate effects. This design combining nanostructure with chemical doping may be exemplary for improved “green” photocatalytic systems.

With the help of a catalyst, sunlight can drive the oxidation of water to oxygen and the release of electrons for current generation, a process also called artificial photosynthesis...

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Pleiades Star Cluster: Surprising variability

This image from NASA’s Kepler spacecraft shows members of the Pleiades star cluster taken during Campaign 4 of the K2 Mission. The cluster stretches across two of the 42 charge-coupled devices (CCDs) that make up Kepler’s 95 megapixel camera. The brightest stars in the cluster – Alcyone, Atlas, Electra, Maia, Merope, Taygeta, and Pleione – are visible to the naked eye. Kepler was not designed to look at stars this bright; they cause the camera to saturate, leading to long spikes and other artefacts in the image. Despite this serious image degradation, the new technique has allowed astronomers to carefully measure changes in brightness of these stars as the Kepler telescope observed them for almost three months. Credit: NASA / Aarhus University / T. White

This image from NASA’s Kepler spacecraft shows members of the Pleiades star cluster taken during Campaign 4 of the K2 Mission. The cluster stretches across two of the 42 charge-coupled devices (CCDs) that make up Kepler’s 95 megapixel camera. The brightest stars in the cluster – Alcyone, Atlas, Electra, Maia, Merope, Taygeta, and Pleione – are visible to the naked eye. Kepler was not designed to look at stars this bright; they cause the camera to saturate, leading to long spikes and other artefacts in the image. Despite this serious image degradation, the new technique has allowed astronomers to carefully measure changes in brightness of these stars as the Kepler telescope observed them for almost three months. Credit: NASA / Aarhus University / T. White

The Seven Sisters, as they ...

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‘Dragonfly’ Dual-Quadcopter aims to explore Titan, Saturn’s largest moon

The Dragonfly dual-quadcopter, shown here in an artist’s rendering, could make multiple flights to explore diverse locations as it characterizes the habitability of Titan’s environment. Credit: APL/Mike Carroll

The Dragonfly dual-quadcopter could make multiple flights to explore diverse locations as it characterizes the habitability of Titan’s environment.
Credit: APL/Mike Carroll

Dragonfly, a New Frontiers-class mission concept that the Johns Hopkins Applied Physics Laboratory has proposed to NASA, would use an instrumented, radioisotope-powered, dual-quadcopter to explore potential habitable sites where life could be developed on Saturn’s largest moon, Titan. The moon is one of a number of “ocean worlds” in our solar system that hold the ingredients for life, and is known to be covered with rich organic material that is undergoing chemical processes that might be similar to those on early Earth, before life developed.

Titan has diverse, carbon-rich chemistry on a surface dominated by water ice...

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