MIT researchers have demonstrated a new way to reverse memory loss by blocking an enzyme known as HDAC2. Credit: Jose-Luis Olivares/MIT

Study suggests a new approach to developing treatments for Alzheimer’s disease. In the brains of Alzheimer’s patients, many of the genes required to form new memories are shut down by a genetic blockade, contributing to the cognitive decline seen in those patients. MIT researchers have now shown that they can reverse memory loss in mice by interfering with the enzyme that forms the blockade. The enzyme HDAC2, turns genes off by condensing them so tightly that they can’t be expressed.

For several years, scientists and pharmaceutical companies have been trying to develop drugs that block this enzyme, but most of these drugs also block other HDAC family membe...

This illustration shows how klotho treatment in mice rapidly improved learning and memory of a hidden platform in a water maze. Credit: Leon et al.

Mice treated with klotho do better on tests of memory and motor skills. In a study that augurs well for the therapeutic potential of klotho – a life-extending protein hormone that a minority of people naturally produce at high levels – scientists at UC San Francisco have found that administering a fragment of the klotho protein to young, aging or impaired mice rapidly improves their cognitive and physical performance.

While previous studies had revealed associations between elevated klotho levels and better cognition, that research had been done with mice genetically engineered to continuously produce high klotho levels and in people carrying g...

A Papertronic, On-Demand and Disposable Biobattery: Saliva-Activated Electricity Generation from Lyophilized Exoelectrogens Preinoculated on Paper. Advanced Materials Technologies, 2017; 1700127 DOI: 10.1002/admt.201700127

Researchers have developed the next step in microbial fuel cells (MFCs): a battery activated by spit that can be used in extreme conditions where normal batteries don’t function. Researchers at Binghamton University, State University of New York have developed the next step in microbial fuel cells (MFCs): a battery activated by spit that can be used in extreme conditions where normal batteries don’t function.

For the last 5 years, Binghamton University Electrical and Computer Science Assistant Professor Seokheun Choi has focused on developing micro-power sources for the ...

Tiny terahertz laser could be used for imaging, chemical detection A new technique boosts the power output of tiny, chip-mounted terahertz lasers by 88 percent. Credit: Demin Liu/Molgraphics

Terahertz radiation—the band of the electromagnetic spectrum between microwaves and visible light—has promising applications in medical and industrial imaging and chemical detection, among other uses. But many of those applications depend on small, power-efficient sources of terahertz rays, and the standard method for producing them involves a bulky, power-hungry, tabletop device. For over 20 years, Prof. Qing Hu at MIT, and his group have been working on sources of terahertz radiation that can be etched onto microchips...