They played a key role in demonstrating the unusual behavior of carbon: Tim Schleif (left) and Joel Mieres Perez (right). Credit: © RUB, Marquard

Chemists at Ruhr-Universität Bochum have found evidence that carbon atoms cannot only behave like particles but also like waves. This quantum-mechanical property is well-known for light particles such as electrons or hydrogen atoms. However, researchers have only rarely observed the wave-particle duality for heavy atoms, such as carbon. “Our result is one of few examples showing that carbon atoms can display quantum effects,” says Sander. Specifically, carbon atoms can tunnel. They thus overcome an energetic barrier, although they do not actually possess enough energy to do that.

Wolfram Sander explains the paradox: “It’s as though a tiger has ...

Creation of a Synthetic Ligand for Mitochondrial DNA Sequence Recognition and Promoter-Specific Transcription Suppression

For the first time, a synthetic compound has been made that can bind to DNA in the cells’ energy powerhouses, suppressing a gene associated with nerve and muscle disease. Pyrrole-imidazole polyamides (PIPs) are compounds that can read specific DNA sequences inside living cells and silence disease-causing genes. They prevent transcription factors, from binding to specific parts of the DNA strand, thus suppressing the transcription of DNA into RNA.

Most DNA is found in the nucleus. But mitochondria, the cell’s powerhouses, also host a small amount of DNA. PIPs can cross the nuclear membrane to bind to nuclear DNA, but are incapable of crossing the mitochondrial membrane...