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    Popular Class of Drugs Reverse potentially Harmful Genetic Changes from Heart Disease

    July 2, 2017, Categories  Health/Medical, Biology/Biotechnology

    Atenolol reverses heart failure symptoms in TAC mice. (a) Experimental design overview. MEF2-LacZ mice (6–8 weeks old) underwent transverse aortic constriction (TAC) or Sham surgeries, followed by Solvent or Atenolol (50 mg/kg/day) treatment (n = 9). (b) Functional analysis of TAC or Sham mouse hearts after four weeks of Atenolol or Solvent treatment. End systolic diameter (ESD), end diastolic diameter (EDD), ejection fraction (EF), fractional shortening (FS), end systolic volume (ESV), end diastolic volume (EDV), left ventricular mass (LV), and left ventricular posterior wall depth (PWDd) were assessed by ultrasound echocardiography. (n = 9), Data are presented as mean ± SEM. *P < 0.05 **P < 0.01 ***P < 0.001 vs Sham + Sol. (c) WGA stain depicting cardiac hypertrophy. Images are representative of an average of n ≥ 10 images per heart, 4 animals per group. Scale bar: 25 µm. Graph below shows cardiomyocyte size (CM cell size), quantified based on an average of ≥10 cell measurements per mouse (n = 4). (d) Masson’s Trichrome stain depicting fibrosis. Images are representative of n = 10 images per heart, 5 animals per group. Cardiomyocytes appear red, nuclei appear black and collagen appears blue. Scale bar: 100 µm. Graph shows quantified cardiomyocyte fibrosis based on a three representative images per mouse (n = 5). Data are presented as mean ± SEM. **P < 0.01 vs Sham + Sol. #P < 0.05 vs TAC + Sol.

    Atenolol reverses heart failure symptoms in TAC mice. (a) Experimental design overview. MEF2-LacZ mice (6–8 weeks old) underwent transverse aortic constriction (TAC) or Sham surgeries, followed by Solvent or Atenolol (50 mg/kg/day) treatment (n = 9). (b) Functional analysis of TAC or Sham mouse hearts after four weeks of Atenolol or Solvent treatment. End systolic diameter (ESD), end diastolic diameter (EDD), ejection fraction (EF), fractional shortening (FS), end systolic volume (ESV), end diastolic volume (EDV), left ventricular mass (LV), and left ventricular posterior wall depth (PWDd) were assessed by ultrasound echocardiography. (n = 9), Data are presented as mean ± SEM. *P < 0.05 **P < 0.01 ***P < 0.001 vs Sham + Sol. (c) WGA stain depicting cardiac hypertrophy...

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    Researchers develop Selective Electrocatalysts to Boost direct Methanol Fuel Cell performance

    July 2, 2017, Categories  Technology/Electronics, Chemistry/Nanotechnology, Physics

    CAS researchers develop selective electrocatalysts to boost direct methanol fuel cell performance

    DMFC assemblies. Schematic illustration showing a DMFC fabricated with selective electrocatalysts at the anode and cathode chambers. Inlet is the photograph of the assembled cell. Credit: YANG Jun

    A research group from the Institute of Process Engineering (IPE), Chinese Academy of Sciences, recently reported the development of a new technology to boost performance of direct methanol fuel cells (DMFCs) using high-concentration methanol as fuel, shedding some light on the design of clean and affordable alternative energy sources for portable electric devices.

    When methanol, the fuel of DMFCs, crosses over from the anode to the cathode through the proton exchange membrane (PEM), fuel cell performance is significantly degraded, creating a major problem for the commercialization of DMFCs...

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    Juno Spacecraft to Fly over Jupiter’s Great Red Spot July 10

    July 2, 2017, Categories  Astronomy/Space

    True color mosaic of Jupiter

    This true color mosaic of Jupiter was constructed from images taken by the narrow angle camera onboard NASA’s Cassini spacecraft on December 29, 2000, during its closest approach to the giant planet at a distance of approximately 10 million kilometers (6.2 million miles). Credits: NASA/JPL/Space Science Institute

    Just days after celebrating its first anniversary in Jupiter orbit, NASA’s Juno spacecraft will fly directly over Jupiter’s Great Red Spot, the gas giant’s iconic, 10,000-mile-wide storm. This will be humanity’s first up-close and personal view of the gigantic feature—a storm monitored since 1830 and possibly existing for more than 350 years...

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    New clues found to common Respiratory Virus

    July 1, 2017, Categories  Health/Medical, Biology/Biotechnology

    Image: Scientists have solved the structure of a protein that helps a common respiratory virus evade the immune system. The team, led by researchers at Washington University School of Medicine in St. Louis, have identified critical parts of the protein that could be targeted with drugs or vaccines, opening up the possibility of preventing or treating an infection that sickens thousands of babies and elderly people every year. Credit: Daisy Leung

    Image: Scientists have solved the structure of a protein that helps a common respiratory virus evade the immune system. The team, led by researchers at Washington University School of Medicine in St. Louis, have identified critical parts of the protein that could be targeted with drugs or vaccines, opening up the possibility of preventing or treating an infection that sickens thousands of babies and elderly people every year.
    Credit: Daisy Leung

    “We solved the structure of a protein that has eluded the field for quite some time,” said Daisy Leung, PhD, an assistant professor of pathology and immunology, and of biochemistry and molecular biophysics at Washington University School of Medicine in St. Louis...

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