Distinct Wiring mode found in Chandelier Cells

AIS but not off-target varicosities predominantly contain presynaptic markers. A, Immunohistochemical analysis of VGAT localization in ChC varicosities in Nkx2.1-CreER;LSL-tGFP mice. Confocal images of a single optical section showing varicosities (green), VGAT (red), and AISs visualized by AnkG immunostaining (blue) in a P16 brain. White and yellow arrowheads indicate AIS and off-target varicosities, respectively. Filled and empty arrowheads show VGAT+ and VGAT- varicosities in ChC axons, respectively. Scale bar, 5 μm. B, The average percentage of VGAT-containing AIS and off-target varicosities in P16 ChCs. The percentage of VGAT-containing AIS varicosities is significantly higher than that of VGAT-containing off-target varicosities (n = 7 ChCs for each; ≥3 brains per condition; Student’s t test: **p < 0.001)h. Data are presented as mean ± SEM. C, Localization of Syp-YFP puncta in varicosities of transplanted ChCs. Confocal images of a single optical section showing AIS visualized by AnkG immunostaining (blue), Syp-YFP (green), and varicosities along the axon (red) in an EP16 brain. White and yellow arrowheads indicate AIS and off-target varicosities, respectively. Filled and empty arrowheads show Syp-YFP+ and Syp-YFP- varicosities in ChC axons, respectively. Scale bar, 5 μm. D, The average percentage of Syp-YFP-containing AIS and off-target varicosities in EP16 ChCs. The percentage of Syp-YFP containing AIS varicosities is significantly higher than that of Syp-YFP containing off-target varicosities (n = 6 ChCs; ≥3 brains; Student’s t test: ***p < 0.001)l. Data are presented as mean ± SEM. E, The average percentage of VGAT-containing AIS and off-target varicosities in P28 ChCs. The percentage of VGAT-containing AIS varicosities is significantly higher than that of VGAT-containing off-target varicosities (n = 7 ChCs for each; ≥3 brains per condition; Student’s t test: ***p < 0.001)°. Data are presented as mean ± SEM.

AIS but not off-target varicosities predominantly contain presynaptic markers. A, Immunohistochemical analysis of VGAT localization in ChC varicosities in Nkx2.1-CreER;LSL-tGFP mice. Confocal images of a single optical section showing varicosities (green), VGAT (red), and AISs visualized by AnkG immunostaining (blue) in a P16 brain. White and yellow arrowheads indicate AIS and off-target varicosities, respectively. Filled and empty arrowheads show VGAT+ and VGAT- varicosities in ChC axons, respectively. Scale bar, 5 μm. B, The average percentage of VGAT-containing AIS and off-target varicosities in P16 ChCs...

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Biodegradable Microbeads made from Cellulose

1. Microbeads are found in cosmetics and personal care products such as toothpaste, sunscreen, hair gel and shower gel. 2. Microscope picture of cellulose microbeads

1. Microbeads are found in cosmetics and personal care products such as toothpaste, sunscreen, hair gel and shower gel.
2. Microscope picture of cellulose microbeads

On World Ocean Day, researchers announced they developed biodegradable cellulose microbeads from a sustainable source that could potentially replace harmful plastic ones that contribute to ocean pollution. Microbeads are little spheres of plastic less than 0.5 mm in size that are added to personal care and cleaning products including cosmetics, sunscreens and fillers to give them a smooth texture. However they are too small to be removed by sewage filtration systems and so end up in rivers and oceans and ingested by birds, fish and marine life.

It is estimated that a single shower can result in 100,000 plastic particles enterin...

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Space-traveling Flatworms help scientists enhance understanding of Regenerative health

1. Flatworm amputation, and space-exposed and Earth-bound worm sample schematics. 2. Amputation of double-headed worm from space results in double-headed morphology  3. Bacterial community composition of Earth-only and space-exposed D. japonica.

1. Flatworm amputation, and space-exposed and Earth-bound worm sample schematics.
2. Amputation of double-headed worm from space results in double-headed morphology
3. Bacterial community composition of Earth-only and space-exposed D. japonica.

Flatworms (D. japonica) that spent 5 weeks aboard ISS are helping researchers led by Tufts University scientists to study how an absence of normal gravity and geomagnetic fields can have anatomical, behavioral, and bacteriological consequences, according to a paper to be published June 13 in Regeneration. The research has implications for human and animal space travelers and for regenerative and bioengineering science.

Planaria are frequently used for studies because of their remarkable ability to regenerate when parts of their bodies are amputated...

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The largest Virtual Universe ever simulated

The Cosmic Web: A section of the virtual universe, a billion light years across, showing how dark matter is distributed in space, with dark matter halos the yellow clumps, interconnected by dark filaments. Cosmic void, shown as the white areas, are the lowest density regions in the Universe. Credit: Joachim Stadel, UZH

The Cosmic Web: A section of the virtual universe, a billion light years across, showing how dark matter is distributed in space, with dark matter halos the yellow clumps, interconnected by dark filaments. Cosmic void, shown as the white areas, are the lowest density regions in the Universe. Credit: Joachim Stadel, UZH

Researchers from the University of Zurich have simulated the formation of our entire Universe with a large supercomputer. A gigantic catalogue of about 25 billion virtual galaxies has been generated from 2 trillion digital particles. This catalogue is being used to calibrate the experiments on board the Euclid satellite, that will be launched in 2020 with the objective of investigating the nature of dark matter and dark energy.

Over 3 years, a group of astrophysicists from t...

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