Tau Prevents Synaptic Transmission at Early stage of Neurodegeneration

Interfering with Tau N-terminal-dependent vesicle-binding reverts Tau-induced presynaptic deficits in fly neurons.

Interfering with Tau N-terminal-dependent vesicle-binding reverts Tau-induced presynaptic deficits in fly neurons. Drosophila larvae used in (a–c) express UAS-TauΔN (R406W, V337M or P301L) under the D42-Gal4 motor neuron driver. (a) FRAP measurements of vesicle mobility within synaptic boutons. Fluoresence recovery (% of initial fluorescence) was plotted over time and fit with double-exponential curves. n=22 (R406W), 20 (ΔN_R406W, ΔN_V337M), 24 (ΔN_P301L) or 25 (Control) boutons (3–5 boutons per animal). (b) Synapto-pHluorin responses to stimulation at 10 Hz with the presence of bafilomycin. Fluorescence change ΔF at ratio to maximal ΔF (NH4Cl dequenching) was plotted over time during the stimulation. Two-way ANOVA, n=7 (R406W, ΔN_R406W, ΔN_V337M, ΔN_P301L),9 (Control) NMJs (animals)...

Read More

Graphene-Nanotube Hybrid boosts Lithium Metal Batteries

1. Lithium metal coats the hybrid graphene and carbon nanotube anode in a battery created at Rice University. The lithium metal coats the three-dimensional structure of the anode and avoids forming dendrites. Courtesy of the Tour Group. 2. A graphic shows carbon nanotubes covalently bonded to a graphene substrate. The material created at Rice University is being tested as an anode for high-capacity lithium metal batteries. Courtesy of the Tour Group - See more at: http://news.rice.edu/2017/05/18/graphene-nanotube-hybrid-boosts-lithium-metal-batteries-2/#sthash.eX5HvXSE.dpuf 3. An electron microscope image shows a carbon nanotube evenly coated with lithium metal. Tests on the graphene-carbon nanotube anode created at Rice University show it resists the formation of lithium dendrites that can damage batteries. Courtesy of the Tour Group

1. Lithium metal coats the hybrid graphene and carbon nanotube anode in a battery created at Rice University. The lithium metal coats the three-dimensional structure of the anode and avoids forming dendrites. Courtesy of the Tour Group.
2. A graphic shows carbon nanotubes covalently bonded to a graphene substrate. The material created at Rice University is being tested as an anode for high-capacity lithium metal batteries. Courtesy of the Tour Group – See more at: http://news.rice.edu/2017/05/18/graphene-nanotube-hybrid-boosts-lithium-metal-batteries-2/#sthash.eX5HvXSE.dpuf
3. An electron microscope image shows a carbon nanotube evenly coated with lithium metal...

Read More

History of Titan’s Landscape resembles that of Mars, not Earth

Left to right: River networks on Mars, Earth, and Titan. Researchers report that Titan, like Mars but unlike Earth, has not undergone any active plate tectonics in its recent past. Credit: Benjamin Black/NASA/Visible Earth/JPL/Cassini RADAR team. Adapted from images from NASA Viking, NASA/Visible Earth, and NASA/JPL/Cassini RADAR team

Left to right: River networks on Mars, Earth, and Titan. Researchers report that Titan, like Mars but unlike Earth, has not undergone any active plate tectonics in its recent past. Credit: Benjamin Black/NASA/Visible Earth/JPL/Cassini RADAR team. Adapted from images from NASA Viking, NASA/Visible Earth, and NASA/JPL/Cassini RADAR team

Rivers on 3 worlds tell different tales. The environment on Titan, Saturn’s largest moon, may seem surprisingly familiar: Clouds condense and rain down on the surface, feeding rivers that flow into oceans and lakes. Outside of Earth, Titan is the only other planetary body in the solar system with actively flowing rivers, though they’re fed by liquid methane instead of water. Long ago, Mars also hosted rivers, which scoured valleys across its now-arid surface...

Read More

Mapping Super Massive Black Holes in the Distant Universe

A slice through largest-ever three-dimensional map of the Universe. Earth is at the left, and distances to galaxies and quasars are labelled by the lookback time to the objects (lookback time means how long the light from an object has been travelling to reach us here on Earth). The locations of quasars (galaxies with supermassive black holes) are shown by the red dots, and nearer galaxies mapped by SDSS are also shown (yellow). The right hand edge of the map is the limit of the observable Universe, from which we see the Cosmic Microwave Background (CMB) – the light “left over” from the Big Bang. Fluctuations in the CMB as observed by the recent ESA Planck satellite mission are shown. The bulk of the empty space in between the quasars and the edge of the observable universe are from the “dark ages”, prior to the formation of most stars, galaxies, or quasars. Credit Anand Raichoor and the SDSS Collaboration.

A slice through largest-ever three-dimensional map of the Universe. Earth is at the left, and distances to galaxies and quasars are labelled by the lookback time to the objects (lookback time means how long the light from an object has been travelling to reach us here on Earth). The locations of quasars (galaxies with supermassive black holes) are shown by the red dots, and nearer galaxies mapped by SDSS are also shown (yellow). The right hand edge of the map is the limit of the observable Universe, from which we see the Cosmic Microwave Background (CMB) – the light “left over” from the Big Bang. Fluctuations in the CMB as observed by the recent ESA Planck satellite mission are shown...

Read More