Trigger for Autoimmune Disease eg Lupus, Crohn’s, MS Identified

T-bet expression in B cells is required for the formation of spontaneous GCs, but is dispensable for the formation GCs following deliberate immunization. (A–C) Representative immunofluorescent staining of 5 spleen sections obtained from (A) SLE × T-betfl/fl × CD19Cre/WT, (B) SLE × T-betfl/fl × CD19WT/WT, or (C) C57BL/6 mice. (D) Percentage of GC B cells identified by FACS as B220+CD19+CD4–CD8–GL7+CD95+ and (E–G) representative immunofluorescent staining of spleens sections obtained from (E) T-betfl/fl × CD19Cre/WT, (F) T-betfl/fl × CD19WT/WT mice immunized with NP-CGG and alum (day 11) (n = 4 mice per group), or (G) naive C57BL/6 mice. n = 4 mice per group, representative of 3 independent experiments. Scale bars: 100 μm. *P < 0.05, **P < 0.01 by 1-way ANOVA followed by Newman-Keuls analysis. NS, not significant; PNA, peanut agglutinin.

T-bet expression in B cells is required for the formation of spontaneous GCs, but is dispensable for the formation GCs following deliberate immunization. (A–C) Representative immunofluorescent staining of 5 spleen sections obtained from (A) SLE × T-betfl/fl × CD19Cre/WT, (B) SLE × T-betfl/fl × CD19WT/WT, or (C) C57BL/6 mice. (D) Percentage of GC B cells identified by FACS as B220+CD19+CD4–CD8–GL7+CD95+ and (E–G) representative immunofluorescent staining of spleens sections obtained from (E) T-betfl/fl × CD19Cre/WT, (F) T-betfl/fl × CD19WT/WT mice immunized with NP-CGG and alum (day 11) (n = 4 mice per group), or (G) naive C57BL/6 mice. n = 4 mice per group, representative of 3 independent experiments. Scale bars: 100 μm. *P < 0.05, **P < 0...

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At last: Beautiful, Consistent Carbon Belts

A carbon nanobelt, represented as a ball-and stick model and space-filing model. Carbon atoms are colored in orange and gray and hydrogen atoms are colored in white. Credit: ITbM, Nagoya University

A carbon nanobelt, represented as a ball-and stick model and space-filing model. Carbon atoms are colored in orange and gray and hydrogen atoms are colored in white.
Credit: ITbM, Nagoya University

Synthesis of a carbon nanobelt with potential applications in nanotechnology. Chemists have tried to synthesize carbon nanobelts for more than 60 years, but none have succeeded until now. A Nagoya University team reported the first organic synthesis of a carbon nanobelt in Science. Carbon nanobelts are expected to serve as a useful template for building carbon nanotubes and open a new field of nanocarbon science.

The new nanobelt, measuring 0...

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3D-Printed ‘Bionic Skin’ could give Robots the Sense of Touch

Screenshot of video (https://youtu.be/GCT0KwFw-pM) showing 3D printing of stretchable electronic sensory devices that could give robots the ability to feel their environment and is a major step forward in printing electronics on real human skin. Credit: Shuang-Zhuang Guo and Michael McAlpine, University of Minnesota

Screenshot of video (https://youtu.be/GCT0KwFw-pM) showing 3D printing of stretchable electronic sensory devices that could give robots the ability to feel their environment and is a major step forward in printing electronics on real human skin. Credit: Shuang-Zhuang Guo and Michael McAlpine, University of Minnesota

Uni of Minnesota engineering researchers have developed a revolutionary process for 3D printing stretchable electronic sensory devices that could give robots the ability to feel their environment. The discovery is also a major step forward in printing electronics on real human skin. “This stretchable electronic fabric we developed has many practical uses,” said A/Prof. Michael McAlpine...

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Observatories Combine to Crack Open the Crab Nebula

An image of the Crab Nebula, a supernova remnant that was assembled by combining data from five telescopes spanning nearly the entire breadth of the electromagnetic spectrum: the Very Large Array, the Spitzer Space Telescope, the Hubble Space Telescope, the XMM-Newton Observatory, and the Chandra X-ray Observatory. Credit: NASA, ESA, NRAO/AUI/NSF and G. Dubner (University of Buenos Aires)

An image of the Crab Nebula, a supernova remnant that was assembled by combining data from five telescopes spanning nearly the entire breadth of the electromagnetic spectrum: the Very Large Array, the Spitzer Space Telescope, the Hubble Space Telescope, the XMM-Newton Observatory, and the Chandra X-ray Observatory.
Credit: NASA, ESA, NRAO/AUI/NSF and G. Dubner (University of Buenos Aires)

Astronomers have produced a highly detailed image of the Crab Nebula, by combining data from telescopes spanning nearly the entire breadth of the electromagnetic spectrum, from radio waves seen by the Karl G. Jansky VLA to the powerful Xray glow as seen by the orbiting Chandra X-ray Observatory...

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