Spiral galaxy NGC 253. The core reveals violent star formation within a region 1, 000 light-years across. A starburst galaxy has an exceptionally high rate of star birth, first identified by its excess of infrared radiation from warm dust. Credit: Carnegie Institution of Washington.Credit: Jay Gallagher (University of Wisconsin-Madison), Alan Watson (Lowell Observatory, Flagstaff, AZ) and NASA/ESA/HST.

Highlights •SIRT1-ΔE2 is a tissue-restricted splice variant of SIRT1 •SIRT1-FL/SIRT1-ΔE2 are indistinguishable vis-à-vis intrinsic catalytic activities •The conserved exon 2 (E2) domain may act to tether substrates •E2 encodes molecular specificity of interactions and functions

vit D pathway

Scheme of the local surface chemistry modification and AuNPs tracking approach. (a) Ag nanoantennas were modified overnight with 1 mM ethanolic solution of 4-NTP. Several ethanol/water washing steps were performed on each sample. (b) 4-NTP-coated antennas were immersed in 0.1 M HCl solution and illuminated for different times at their LSPR wavelength (633 nm) with a power density of 1 W cm−2. Samples were rinsed with water and immediately dipped in the activated AuNP suspension. (c) AuNPs (15 nm) coated with 11-mercaptoundecanoic acid (MUA) as a capping layer were suspended in HEPES buffer and mixed with 1 mM EDC and 1 mM NHS, and left to react for 30 min followed by two purification centrifugation steps...