Researchers Identify a New Way to Promote Tissue Regeneration Activating Innate Immunity Induces Pluripotency

Cell (stock image). The use of iPSCs to generate tissues would revolutionize transplantation, facilitating the growth of artificial organs, say authors. Credit: © dedigrigoroiu / Fotolia

Cell (stock image). The use of iPSCs to generate tissues would revolutionize transplantation, facilitating the growth of artificial organs, say authors. Credit: © dedigrigoroiu / Fotolia

Houston Methodist researchers have identified an immune pathway that promotes the formation of a cell that can develop into new tissues and organs. In a new study published in the journal Stem Cells, a team led by John P. Cooke, M.D., Ph.D, described how activation of innate immunity enhances nuclear reprogramming, one of the first steps in tissue regeneration, or the formation of new tissues and organs from a single cell in the body.

“We found that activating the innate immune system opens up the DNA,” said Cooke, the study’s senior author...

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Using Nature to Build Nanomachines

1. Schematic diagram of the bacterial flagellar basal body with name and size of each part. 2. Molecular models of the flagellar rod (purple) and hook (blue green) and their comparison. (a) The model of the rod and hook complex including their direct connection in a section along their tubular axis. The structures of their corresponding domains are nearly identical. (b) Structural comparison of the rod and hook subunits by superposition. Domain D1 of the hook protein is more tilted than that of the rod protein by 7°, producing a gap between subunits in the axial neighbors to make the entire hook flexible in bending. (c) The C-terminal helix (blue) of the hook is shorter than that of the rod, making an axial gap between subunits in the hook structure but not in the rod.

1. Schematic diagram of the bacterial flagellar basal body with name and size of each part.
2. Molecular models of the flagellar rod (purple) and hook (blue green) and their comparison. (a) The model of the rod and hook complex including their direct connection in a section along their tubular axis. The structures of their corresponding domains are nearly identical. (b) Structural comparison of the rod and hook subunits by superposition. Domain D1 of the hook protein is more tilted than that of the rod protein by 7°, producing a gap between subunits in the axial neighbors to make the entire hook flexible in bending. (c) The C-terminal helix (blue) of the hook is shorter than that of the rod, making an axial gap between subunits in the hook structure but not in the rod.

Scientists have imag...

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Machine Learning writes Songs that Elicits Emotions from its listeners

This is a Brain Music EEG headset. Credit: Osaka University

This is a Brain Music EEG headset. Credit: Osaka University

Music, more than any art, is a beautiful mix of science and emotion. It follows a set of patterns almost mathematically to extract feelings from its audience. Machines that make music focus on these patterns, but give little consideration to the emotional response of their audience. An international research team led by Osaka University together with Tokyo Metropolitan University, imec in Belgium and Crimson Technology has released a new machine-learning device that detects the emotional state of its listeners to produce new songs that elicit new feelings.

“Most machine songs depend on an automatic composition system,” says Masayuki Numao, professor at Osaka University...

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Studying Magnetic Space Explosions with NASA missions

simulation of magnetic reconnection event

In this simulation, a reconnection even pushes a blob of plasma toward Earth. The jet blown in the opposite direction wobbles due to the unstable conditions. Credit: NASA’s Goddard Space Flight Center/Yi-Hsin Liu/Joy Ng, producer

Every day, invisible magnetic explosions are happening around Earth, on the surface of the sun and across the universe. These explosions, known as magnetic reconnection, occur when magnetic field lines cross, releasing stored magnetic energy. Such explosions are a key way that clouds of charged particles – plasmas – are accelerated throughout the universe. In Earth’s magnetosphere – the giant magnetic bubble surrounding our planet — these magnetic reconnections can fling charged particles toward Earth, triggering auroras.

Magnetic reconnection, in addition to push...

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