Longevity-promoting Superstar gets revealed in Caenorhabditis Reproducibility Project

(a–c) Dose response effects on the median lifespan of select C. briggsae strains after treatment with chemicals that exhibited strong positive effects on the C. elegans strains. Dosing was performed only on strains that failed to respond positively in the initial tests (single dose experiments), as we did not attempt to identify peak responses, instead we only sought to identify whether positive effects could be obtained by altering doses. Chemical doses were chosen to center around the effective dose identified for C. elegans strains and were sometimes expanded after preliminary rounds of testing. ThT exhibited a positive effect on strain JU1348 at 25 μM, but was profoundly toxic to all strains at and above 100 μM

(a–c) Dose response effects on the median lifespan of select C. briggsae strains after treatment with chemicals that exhibited strong positive effects on the C. elegans strains. Dosing was performed only on strains that failed to respond positively in the initial tests (single dose experiments), as we did not attempt to identify peak responses, instead we only sought to identify whether positive effects could be obtained by altering doses. Chemical doses were chosen to center around the effective dose identified for C. elegans strains and were sometimes expanded after preliminary rounds of testing. ThT exhibited a positive effect on strain JU1348 at 25 μM, but was profoundly toxic to all strains at and above 100 μM

The amyloid dye Thioflavin T emerged as the superstar when age rese...

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Drug Rx could Combat Hearing Loss

This is a photograph of large clonal colonies of cochlear progenitor cells formed from single cells and converted into high purity colonies hair cells (magenta) with intricate hair bundles (cyan). Credit: Will McLean, Ph.D. Newly formed cochlear hair cells contain intricate hair bundles with many stereocilia (critical for sensing sound) and other components that are critical for proper function and neural transmission. (Credit: Will McLean)

1. photograph of large clonal colonies of cochlear progenitor cells formed from single cells and converted into high purity colonies hair cells (magenta) with intricate hair bundles (cyan). Credit: Will McLean, Ph.D.  2. Newly formed cochlear hair cells contain intricate hair bundles with many stereocilia (critical for sensing sound) and other components that are critical for proper function and neural transmission. (Credit: Will McLean)

Researchers discover a drug combination that can regenerate hair cells. Within the inner ear, thousands of hair cells detect sound waves and translate them into nerve signals that allow us to hear speech, music, and other everyday sounds. Damage to these cells is one of the leading causes of hearing loss, which affects 48 million Americans...

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Scalable 100% yield production of Conductive Graphene Inks

We report the exfoliation of graphite in aqueous solutions under high shear rate [∼ 108 s–1] turbulent flow conditions, with a 100% exfoliation yield. The material is stabilized without centrifugation at concentrations up to 100 g/L using carboxymethylcellulose sodium salt to formulate conductive printable inks. The sheet resistance of blade coated films is below ∼2Ω/□. This is a simple and scalable production route for conductive inks for large-area printing in flexible electronics.

We report the exfoliation of graphite in aqueous solutions under high shear rate [∼ 108 s–1] turbulent flow conditions, with a 100% exfoliation yield. The material is stabilized without centrifugation at concentrations up to 100 g/L using carboxymethylcellulose sodium salt to formulate conductive printable inks. The sheet resistance of blade coated films is below ∼2Ω/□. This is a simple and scalable production route for conductive inks for large-area printing in flexible electronics.

Conductive inks are useful for a range of applications, including printed and flexible electronics such as radio frequency identification (RFID) antennas, transistors or photovoltaic cells...

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Switched-on DNA: Sparking Nano-Electronic Applications

EC gate control of DNA conductance. (a) Illustration of the experiment, where the source and drain electrodes are the STM tip and substrate, and EC gate is a silver electrode inserted in the solution. A DNA molecule bridged between the source and drain electrodes via the thiolate linker groups, where charge hops from one base to the next (red arrows) via overlapping π-orbitals. The source-drain bias (Vds), and the EC gate voltage (Vg) are controlled independently. (b) From left to right: redox modified DNA (Aq-DNA), where a base was replaced with an anthraquinone (Aq) moiety (highlighted in blue) at the 3′-end of a DNA strand (see chemical structure in Supplementary Fig. 1a); three-dimensional structure (PDB ID: 2KK5, results are from nuclear magnetic resonance study17) shows that the Aq moiety intercalated in between the two Guanine bases on the other strand acts as a hopping site (red arrows) with its π-orbital overlapping with those from adjacent bases. Aq moiety is shown in blue. Picture is created from 2KK5 in PDB with JSmol software. DNA without the Aq moiety (u-DNA) was studied as control. Both Aq-DNA and u-DNA contain a strand terminated with thiolated linkers at the 3′- and 5′-ends for contact with the source and drain electrodes.

EC gate control of DNA conductance.

DNA may very well also pack quite the jolt for engineers trying to advance the development of tiny, low-cost electronic devices. Much like flipping your light switch at home – only on a scale 1,000 times smaller than a human hair – an ASU-led team has developed the first controllable DNA switch to regulate the flow of electricity within a single, atomic-sized molecule.

“It has been established that charge transport is possible in DNA, but for a useful device, one wants to be able to turn the charge transport on and off. We achieved this goal by chemically modifying DNA,” said Tao, who directs the Biodesign Center for Bioelectronics and Biosensors and is a professor in the Fulton Schools of Engineering...

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