Drug Compound Halts Alzheimer’s-related damage in Mice

In some people, the brain protein tau collects into toxic tangles that damage brain cells and contribute to diseases such as Alzheimer's. Researchers at Washington University School of Medicine in St. Louis have found a drug that can lower tau levels and prevent some neurological damage. In neurons that contain the drug (above, in red) there are no tau tangles (in green). Credit: Sarah DeVos

In some people, the brain protein tau collects into toxic tangles that damage brain cells and contribute to diseases such as Alzheimer’s. Researchers at Washington University School of Medicine in St. Louis have found a drug that can lower tau levels and prevent some neurological damage. In neurons that contain the drug (above, in red) there are no tau tangles (in green). Credit: Sarah DeVos

Appears to reverse some neurological harm. Under ordinary circumstances, the protein tau contributes to the normal, healthy functioning of brain neurons. In some people, though, it collects into toxic tangles that damage brain cells. Such tangles are a hallmark of Alzheimer’s and other neurodegenerative diseases. But researchers at Washington University School of Medicine in St...

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New Sensors can Detect single Protein Molecules

MIT chemical engineers have developed arrays of carbon nanotube sensors that can detect single protein molecules as they are secreted from cells. Credit: Courtesy of the researchers

MIT chemical engineers have developed arrays of carbon nanotube sensors that can detect single protein molecules as they are secreted from cells. Credit: Courtesy of the researchers

Modified carbon nanotubes could be used to track protein production by individual cells eg tracking viral infection, monitoring cell manufacture of useful proteins, or revealing food contamination. “We hope to use sensor arrays like this to look for the ‘needle in a haystack,'” says Michael Strano, the Carbon P. Dubbs Professor of Chemical Engineering at MIT. “These arrays represent the most sensitive molecular sensing platforms that we have available to us technologically. You can functionalize them so you can see the stochastic fluctuations of single molecules binding to them.”

Strano’s lab has previously dev...

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Protective Wear Inspired by Fish Scales

Stretch-and-release fabrication, testing and optimization of a flexible ceramic armor inspired from fish scales,” by Robert Martini and François Barthelat, Bioinspiration and Biomimetics: http://iopscience.iop.org/article/10.1088/1748-3190/11/6/066001

Stretch-and-release fabrication, testing and optimization of a flexible ceramic armor inspired from fish scales,” by Robert Martini and François Barthelat, Bioinspiration and Biomimetics: http://iopscience.iop.org/article/10.1088/1748-3190/11/6/066001

Ceramic-covered gloves offer industrial workers increased protection from piercing. They started with striped bass. Over a 2-year period the researchers went through about 50 bass, puncturing or fracturing hundreds of fish scales under the microscope, to try to understand their properties and mechanics better. “The people at the fish market must have wondered what we were up to,” says François Barthelat smiling ruefully...

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Astronomers find 7 Dwarf-Galaxy Groups, the Building Blocks of Massive Galaxies

TNT dwarf groups.

TNT dwarf groups. Three colour images of four of the dwarf groups obtained with the Maryland–Magellan Tunable Filter (MMTF) Fabry Perot (Δλ = 10 Å) for dm1049+09 (top left), dm1349-02 (top right) and dm1623+15 (bottom left), and with the Gemini Multi-Object Spectrograph (Δλ = 50 Å) for dm1719+30 (bottom right). Red corresponds to Hα, green corresponds to MMTF or Gemini r-band, and blue corresponds to SDSS g-band. Velocities derived from optical spectroscopy are noted for each group member.

Dwarf galaxies, nuggets of stars and gas 100 to 1,000 times smaller than the Milky Way, are thought to be the building blocks of massive galaxies. Evidence for groups of merging dwarf galaxies, however, has been lacking, until now...

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