Mediterranean Diet may have Lasting Effects on Brain Health

The Mediterranean diet includes large amounts of fruits, vegetables, olive oil, beans and cereal grains such as wheat and rice, moderate amounts of fish, dairy and wine, and limited red meat and poultry. Credit: © marrakeshh / Fotolia

The Mediterranean diet includes large amounts of fruits, vegetables, olive oil, beans and cereal grains such as wheat and rice, moderate amounts of fish, dairy and wine, and limited red meat and poultry. Credit: © marrakeshh / Fotolia

A new study shows that older people who followed a Mediterranean diet retained more brain volume over a 3 year period than those who did not follow the diet as closely. But contrary to earlier studies, eating more fish and less meat was not related to changes in the brain. The Mediterranean diet includes large amounts of fruits, vegetables, olive oil, beans and cereal grains such as wheat and rice, moderate amounts of fish, dairy and wine, and limited red meat and poultry.

“As we age, the brain shrinks and we lose brain cells which can affect learning and me...

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Unexpected Role for Epigenetic Enzymes in Cancer

KDM5s are involved in selection of polyA sites. (A) Western blot and (B) RT-qPCR analyses of MCF7 cells treated with dimethyl sulfoxide (DMSO) or 10 μM KDM5-C70 for 3 days. The ratio of 3′UTR to CDS for CCND1 mRNA was plotted. Error bars represent SEM for biological triplicate experiments. (C) Western blot and (D) RT-qPCR analyses of HeLa cells treated with DMSO or 10 μM KDM5-C70 for 3 days. The ratio of 3′UTR to CDS for DICER1 mRNA was plotted. Error bars represent SEM for biological triplicate experiments. **P < 0.01. (E) RT-qPCR analysis of HeLa/iCas9-c1 cells transduced with lentiviruses carrying single-guide RNAs against KDM5A, KDM5B, KDM5C, or nontargeting control. The ratio of 3′UTR to CDS for DICER1 mRNA was plotted. KO, knockout. Error bars represent SEM for biological triplicate experiments. *P < 0.05; **P < 0.01. (F) Working model for KDM5 involvement in APA. KDM5 recruits the polyA machinery to nascent RNA to modulate polyA site choices. Demethylation or hydroxylation of certain subunits of the polyA machinery by KDM5 also contributes to selection of the polyA sites. The polyA sites (dashes) are noted on the nascent transcript.

KDM5s are involved in selection of polyA sites. (A) Western blot and (B) RT-qPCR analyses of MCF7 cells treated with dimethyl sulfoxide (DMSO) or 10 μM KDM5-C70 for 3 days. The ratio of 3′UTR to CDS for CCND1 mRNA was plotted. Error bars represent SEM for biological triplicate experiments. (C) Western blot and (D) RT-qPCR analyses of HeLa cells treated with DMSO or 10 μM KDM5-C70 for 3 days. The ratio of 3′UTR to CDS for DICER1 mRNA was plotted. Error bars represent SEM for biological triplicate experiments. **P < 0.01. (E) RT-qPCR analysis of HeLa/iCas9-c1 cells transduced with lentiviruses carrying single-guide RNAs against KDM5A, KDM5B, KDM5C, or nontargeting control. The ratio of 3′UTR to CDS for DICER1 mRNA was plotted. KO, knockout...

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Intel announces Compute Card, offers Brain Power for Smart Gadgets, Kiosks

Intel announces Compute Card, offers brain power for smart gadgets, kiosks

A new modular compute platform called the Compute Card

We may be about to enter a brand new age of tiny computing. Tech blog MSPoweruser said on Thursday that “At CES 2017 today, Intel announced a new modular compute platform called the Compute Card.” A BBC presenter points in the video to a “fully functional Windows 10 PC. “And when I say this, I actually mean this.” He reaches for a small slab, and tells viewers that it is a complete computer. Processer, storage, memory, Wifi, there. “It is about as powerful as an ultra-thin laptop,” he said.

The Intel Compute Card can operate as a PC or act as the brains of other electronics. The card does not seem to have—anywhere to plug anything in...

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A Flexible Transistor that conforms to Skin

A researcher demonstrates the efficacy of a flexible transistor, as it is stretched, twisted and poked. Credit: J. Xu et al., Science (2016)

A researcher demonstrates the efficacy of a flexible transistor, as it is stretched, twisted and poked. Credit: J. Xu et al., Science (2016)

Researchers have created a stretchy transistor that can be elongated to twice its length with only minimal changes in its conductivity. The development is a valuable advancement for the field of wearable electronics. To date, it has been difficult to design a transistor using inherently stretchable materials that maintains its conductivity upon being stretched. Jie Xu devised a clever and scalable way to confine organic conductors inside a rubbery polymer to create stretchy transistors. They took a semiconducting polymer, called DPPT-TT, and confined it inside another polymer, SEBS, which has elastic properties.

As the two polymers don’t like to mix w...

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