New Gene Therapy could Alleviate Chronic Pain, Researchers find

Researchers create gene therapy with potential to treat peripheral pain conditions
Credit: Cell (2024). DOI: 10.1016/j.cell.2024.11.001

Pain is meant to be a defense mechanism. It creates a strong sensation to get us to respond to a stimulus and prevent ourselves from further harm. But, sometimes injuries, nerve damage, or infections can cause long-lasting, severe bouts of pain that can make daily life unbearable.

What if there was a way to simply turn off pain receptors? UNC School of Medicine researchers Bryan L. Roth, MD, Ph.D., the Michael Hooker Distinguished Professor of Pharmacology, and Grégory Scherrer, PharmD, Ph.D., associate professor of cell biology and physiology and the UNC Neuroscience Center, have just proven that it is possible.

Using a tool designed by Roth in the early 2000s, the labs have created a new system that reduces acute and tissu...

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Tiny Particle, Huge Potential: Scientists discover New Type of Quasiparticle Present in all Magnetic Materials

Researchers recently made a groundbreaking discovery on the nanoscale: a new type of quasiparticle found in all magnetic materials, no matter their strength or temperature. These new properties shake up what researchers previously knew about magnetism, showing it’s not as static as once believed.

“Emergent topological quasiparticle kinetics in constricted nanomagnets,” was published in Physical Review Research. The researchers include Deepak Singh and Carsten Ullrich from the University of Missouri’s College of Arts and Science, along with their teams of students and postdoctoral fellows.

“We’ve all seen the bubbles that form in sparkling water or other carbonated drink products,” said Ullrich, Curators’ Distinguished Professor of Physics and Astronomy...

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First-ever Binary Star Found Near our Galaxy’s Supermassive Black Hole

An international team of researchers has detected a binary star orbiting close to Sagittarius A*, the supermassive black hole at the center of our galaxy. It is the first time a stellar pair has been found in the vicinity of a supermassive black hole.

The discovery, based on data collected by the European Southern Observatory’s Very Large Telescope (ESO’s VLT), helps us understand how stars survive in environments with extreme gravity, and could pave the way for the detection of planets close to Sagittarius A*.

“Black holes are not as destructive as we thought,” says Florian Peißker, a researcher at the University of Cologne, Germany, and lead author of the study published in Nature Communications.

Binary stars, pairs of stars orbiting each other, are very common in the univ...

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Brain Regions that Relieve Effects of Chronic Stress in Mice Differ based on Sex

Schematic of cortical microcircuit showing connections among neurons and how activation of SST neurons leads to stress resilience
New research finds sex-specific regions of the brain can relieve the detrimental effects of chronic stress in male and female mice. Left: Schematic showing a cortical microcircuit with three types of interneurons expressing somatostatin (SST), parvalbumin (PV) or vasointestinal peptide (VIP) and their distinct patterns of innervation of glutamatergic output neurons (PNs), with thin lines representing axons that send chemical signals and the thicker lines of PNs representing dendrites that receive information. There is selective innervation of the distal ends of PN dendrites by axons of SST neurons...
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