How Stress Changes our Memories: Engrams and the Endocannabinoid system may inform new PTSD treatments

memory
Credit: Pixabay/CC0 Public Domain

Researchers at The Hospital for Sick Children (SickKids) have uncovered that stress changes how our brain encodes and retrieves aversive memories, and discovered a promising new way to restore appropriate memory specificity in people with post-traumatic stress disorder (PTSD).

If you stumble during a presentation, you might feel stressed the next time you have to present because your brain associates your next presentation with that one poor and aversive experience. This type of stress is tied to one memory.

But stress from traumatic events like violence or generalized anxiety disorder can spread far beyond the original event, known as stress-induced aversive memory generalization, where fireworks or car backfires can trigger seemingly unrelated ...

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Metalenses Harness AI for High-Resolution, Full-Color Imaging for Compact Optical Systems

A metalens, composed of an array of nanostructures with arbitrary rotational angles, acquires an image, which is restored to generate an output image that closely approximates the quality of the original “ground truth” image
A metalens, composed of an array of nanostructures with arbitrary rotational angles, acquires an image, which is restored to generate an output image that closely approximates the quality of the original “ground truth” image. Credit: Seo et al., doi 10.1117/1.AP.6.6.066002

Modern imaging systems, such as those used in smartphones, virtual reality (VR), and augmented reality (AR) devices, are constantly evolving to become more compact, efficient, and high-performing. Traditional optical systems rely on bulky glass lenses, which have limitations like chromatic aberrations, low efficiency at multiple wavelengths, and large physical sizes. These drawbacks present challenges when designing smaller, lighter systems that still produce high-quality images.

To overcome these issues, rese...

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NASA Satellites reveal Abrupt Drop in Global Freshwater Levels

An angular statellite orbits high over the earth in an artists ipression of the GRACE mission. A radar and laser beams link the satellite to a companion satallite far in the distance.
GRACE satellites measure gravity as they orbit the planet to reveal shifting levels of water on the Earth (artist’s concept).
NASA/JPL-Caltech

An international team of scientists using observations from NASA-German satellites found evidence that Earth’s total amount of freshwater dropped abruptly starting in May 2014 and has remained low ever since. Reporting in Surveys in Geophysics, the researchers suggested the shift could indicate Earth’s continents have entered a persistently drier phase.

From 2015 through 2023, satellite measurements showed that the average amount of freshwater stored on land—that includes liquid surface water like lakes and rivers, plus water in aquifers underground—was 290 cubic miles (1,200 cubic km) lower than the average levels from 2002 through 2014, said...

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Cholesterol may Not be the Only Lipid involved in Trans Fat-driven Cardiovascular Disease

Cholesterol is not the only lipid involved in trans fat-driven cardiovascular disease
Graphical abstract. Credit: Cell Metabolism (2024). DOI: 10.1016/j.cmet.2024.10.016

Excess cholesterol is known to form artery-clogging plaques that can lead to stroke, arterial disease, heart attack, and more, making it the focus of many heart health campaigns. Fortunately, this attention to cholesterol has prompted the development of cholesterol-lowering drugs called statins and lifestyle interventions like dietary and exercise regimens. But what if there’s more to the picture than just cholesterol?

New research from Salk Institute scientists describes how another class of lipids, called sphingolipids, contributes to arterial plaques and atherosclerotic cardiovascular disease (ASCVD)...

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