Brain Regions that Relieve Effects of Chronic Stress in Mice Differ based on Sex

Schematic of cortical microcircuit showing connections among neurons and how activation of SST neurons leads to stress resilience
New research finds sex-specific regions of the brain can relieve the detrimental effects of chronic stress in male and female mice. Left: Schematic showing a cortical microcircuit with three types of interneurons expressing somatostatin (SST), parvalbumin (PV) or vasointestinal peptide (VIP) and their distinct patterns of innervation of glutamatergic output neurons (PNs), with thin lines representing axons that send chemical signals and the thicker lines of PNs representing dendrites that receive information. There is selective innervation of the distal ends of PN dendrites by axons of SST neurons...
Read More

Harnessing Spin: New Electrocatalysts could Transform Hydrogen Production Efficiency

Using chiral topological semimetals as electrocatalysts to enhance the oxygen evolution reaction
Credit: OpenAI Dall-E.

Electrocatalytic water splitting, a process that entails breaking down water into hydrogen and oxygen, is a promising approach to produce clean hydrogen for fuel cells, which could in turn be used to power large electric vehicles. So far, the real-world use of this process has been limited by the sluggish kinetics of the oxygen evolution reaction (OER), a key chemical reaction occurring at the anode.

Researchers at Max-Planck-Institute for Chemical Physics of Solids, Weizmann Institute of Science and other institutes recently introduced an innovative approach to accelerate this reaction, using topological chiral semimetals as electrocatalysts.

Their findings, published in Nature Energy, demonstrate that spin-orbit coupling (SOC) inherent in these materials ...

Read More

Does the Exoplanet Trappist-1 b have an Atmosphere after all?

New observations reveal the challenges of detecting planetary atmospheres

Recent measurements with the James Webb Space Telescope (JWST) cast doubt on the current understanding of the exoplanet Trappist-1 b’s nature. Until now, it was assumed to be a dark rocky planet without an atmosphere, shaped by a billion-year-long cosmic impact of radiation and meteorites. The opposite appears to be true. The surface shows no signs of weathering, which could indicate geological activity such as volcanism and plate tectonics. Alternatively, a planet with a hazy atmosphere composed of carbon dioxide is also viable. The results demonstrate the challenges of determining the properties of exoplanets with thin atmospheres.

Trappist-1 b is one of seven rocky planets orbiting the star Trappist-1, ...

Read More

Researchers Find Previously Unknown Links between Microbial Bile Acids and the Risk of Colon Cancer

Microbes living in our guts help us digest food by reshaping the bile acids that our livers produce for breaking down fats. It turns out that two of these microbially-modified bile acids may affect our risk—in opposite directions—for developing colon cancer.

The link between these bile acids and colon cancer risk was recently uncovered as University of Wisconsin–Madison scientists sought to better understand the relationship between gut microbes and our bodies.

In many ways, that relationship revolves around a specific protein called the farnesoid X receptor, or FXR, which helps maintain a healthy gut through its intimate relationship with bile acids...

Read More