Spinning Artificial Spider Silk into Next-Generation Medical Materials

A microscope image of several small, pyramid shaped needles with thin strands being pulled from them.
Scientists are creating artificial spider silk by drawing strands from an array of tiny hollow needles, as shown here, similar to how arachnids do it.
Adapted from ACS Nano 2024, DOI: 10.1021/acsnano.4c08557

It’s almost time to dust off the Halloween decorations and adorn the house with all manner of spooky things, including the classic polyester spider webs. Scientists reporting in ACS Nano have made their own version of fake spider silk, but this one consists of proteins and heals wounds instead of haunting hallways. The artificial silk is strong enough to be woven into bandages that helped treat hoint injuries and skin lesions in mice.

Spider silk is one of the strongest materials on Earth, technically stronger than steel for a material of its size.

However, it’s tough to obtai...

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Language Agents Help Large Language Models ‘Think’ Better and Cheaper

Language agents help large language models 'think' better and cheaper
An example of the agent producing task-specific instructions (highlighted) for a classification dataset IMDB. The agent only runs once to produce the instructions. Then, the instructions are used for all our models during reasoning. Credit: arXiv (2023). DOI: 10.48550/arxiv.2310.03710

The LLMs that have increasingly taken over the tech world are not “cheap” in many ways. The most prominent LLMs, such as GPT-4, took some $100 million to build in the form of legal costs of accessing training data, computational power costs for what could be billions or trillions of parameters, the energy and water needed to fuel computation, and the many coders developing the training algorithms that must run cycle after cycle so the machine will “learn.”

But, if a researcher needs to do a specializ...

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What happens to the Climate when Earth Passes Through Interstellar Clouds?

Noctilucent clouds were once thought to be a fairly modern phenomenon. A team of researchers recently calculated that Earth and the entire solar system may well have passed through two dense interstellar clouds, causing global noctilucent clouds that may have driven an ice age.

The event is thought to have happened 7 million years ago and would have compressed the heliosphere, exposing Earth to the interstellar medium.

Interstellar clouds are vast regions of gas and dust between the stars within galaxies. They are mostly made up of hydrogen along with a little helium and trace elements of heavier elements.

They are a key part of the life cycle of stars, providing the materials for new stars to be formed, and are seeded with elements after stars die...

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Compact ‘Gene Scissors’ enable Effective Genome Editing, may offer Future Treatment of High Cholesterol Gene Defect

Compact
In Gerold Schank’s lab, researchers from the University of Zurich have used protein engineering and an AI model to make the protein TnpB much more effective for genome editing. Credit: Christian Reichenbach

CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known “gene scissors” but is much smaller and thus easier to transport into cells.

Using protein engineering and AI algorithms, University of Zurich researchers have now enhanced TnpB capabilities to make DNA editing more efficient and versatile, paving the way for treating a genetic defect for high cholesterol in the future. The work has been published in Nature Methods.

CRISPR-Cas systems, which consist of protein and RNA components, we...

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