Drugs for the K-Ras oncogene inspire an approach for targeting the GTPases, a family of enzymes whose dysfunction can lead to Parkinson’s and many other diseases.

UCSF scientists have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases from Parkinson’s to cancer and have long been thought to be “undruggable.”

Because of their slippery exteriors, the GTPases have remained largely out of reach of modern drug discovery, with the exception of the notorious cancer-causing GTPase called K-Ras.

On a hunch, the team tested a dozen drugs that target K-Ras against a handful of GTPases they had mutated to mak...

A new, cheap, easily manufactured device could lead to improved satellite communication, high speed data transmission, and remote sensing, scientists say.

A team of engineers led by researchers from the University of Glasgow have developed an ultrathin 2D surface that harnesses the unique properties of metamaterials to manipulate and convert radio waves across the frequencies most commonly used by satellites.

Metamaterials are structures that have been carefully engineered to imbue them with properties that don’t exist in naturally occurring materials.

The team’s metamaterial, unveiled today in a new paper published in the ...

In a new study, astronomers report novel evidence regarding the limits of planet formation, finding that after a certain point, planets larger than Earth have difficulty forming near low-metallicity stars.

Using the sun as a baseline, astronomers can measure when a star formed by determining its metallicity, or the level of heavy elements present within it. Metal-rich stars or nebulas formed relatively recently, while metal-poor objects were likely present during the early universe.

Previous studies found a weak connection between metallicity rates and planet formation, noting that as a star’s metallicity goes down, so, too, does planet formation for certain planet populations, like sub-Saturns or sub-Neptunes.

Yet this work is the first to observe that under current theories...

Researchers have uncovered how hormones profoundly affect our immune systems, explaining why men and women are affected by diseases differently.

Scientists from the Karolinska Institutet in Sweden and Imperial College London have shown for the first time which aspects of our immune systems are regulated by sex hormones, and the impacts this has on disease risk and health outcomes in males and females.

It is well established that diseases can affect men and women differently, due to subtle differences in our immune systems. For example, the immune condition systemic lupus erythematosus (SLE) is nine-times more likely to affect women, or with COVID-19, males are known to have a greater risk of acute first-time infections, while females have a greater risk of long-COVID.

But it ...