Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also — in a particular subset of T cells — cause mitochondrial stress, DNA damage and cell death, Vanderbilt University Medical Center researchers have discovered.

The findings, published Sept. 20 in the journal Science Immunology, offer a mechanistic understanding for how cells respond to heat and could explain how chronic inflammation contributes to the development of cancer.

The impact of fever temperatures on cells is a relatively understudied area, said Jeff Rathmell, PhD, Cornelius Vanderbilt Professor of Immunobiology and corresponding author of the new study...

The interlocking bricks, which can be repurposed many times over, can withstand similar pressures as their concrete counterparts. Engineers developed a new kind of reconfigurable masonry made from 3D-printed, recycled glass. The bricks could be reused many times over in building facades and internal walls.

What if construction materials could be put together and taken apart as easily as LEGO bricks? Such reconfigurable masonry would be disassembled at the end of a building’s lifetime and reassembled into a new structure, in a sustainable cycle that could supply generations of buildings using the same physical building blocks.

That’s the idea behind cir...

By staring into the hellish landscape of Jupiter’s moon Io – the most volcanically active location in the solar system – Cornell University astronomers have been able to study a fundamental process in planetary formation and evolution: tidal heating.

“Tidal heating plays an important role in the heating and orbital evolution of celestial bodies,” said Alex Hayes, professor of astronomy.

“It provides the warmth necessary to form and sustain subsurface oceans in the moons around giant planets like Jupi...

University of Southampton scientists have stored the full human genome on a 5D memory crystal—a revolutionary data storage format that can survive for billions of years.

The team hope that the crystal could provide a blueprint to bring humanity back from extinction thousands, millions or even billions of years into the future, should science allow.

The technology could also be used to create an enduring record of the genomes of endangered plant and animal species faced with extinction.

Eternity crystals
The 5D memory crystal was developed by the University of Southampton’s Optoelectronics Research Center (ORC).

Unlike other data storage formats that degrade over time, 5D memory crystals can store up to 360 terabytes of information (in the largest size) without loss for bi...