Beyond CRISPR: seekRNA delivers a New Pathway for Accurate Gene Editing

Beyond CRISPR: seekRNA delivers a new pathway for accurate gene editing
IS1111 and IS110 family features. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-49474-9

Scientists at the University of Sydney have developed a gene-editing tool with greater accuracy and flexibility than the industry standard, CRISPR, which has revolutionized genetic engineering in medicine, agriculture and biotechnology.

SeekRNA uses a programmable ribonucleic acid (RNA) strand that can directly identify sites for insertion in genetic sequences, simplifying the editing process and reducing errors.

The new gene-editing tool is being developed by a team led by Dr. Sandro Ataide in the School of Life and Environmental Sciences. Their findings have been published in Nature Communications.

“We are tremendously excited by the potential for this technology...

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How Nvidia became an AI Giant

NVIDIA
Credit: Pixabay/CC0 Public Domain

It all started at a Denny’s in San Jose in 1993. Three engineers—Jensen Huang, Chris Malachowsky and Curtis Priem—gathered at the diner in what is now the heart of Silicon Valley to discuss building a computer chip that would make graphics for video games faster and more realistic. That conversation, and the ones that followed, led to the founding of Nvidia, the tech company that soared through the ranks of the stock market to briefly top Microsoft as the most valuable company in the S&P 500 this week.

The company is now worth over $3.2 trillion, with its dominance as a chipmaker cementing Nvidia’s place as the poster child of the artificial intelligence boom—a moment that Huang, Nvidia’s CEO, has dubbed “the next industrial revolution.”

On...

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Slingshotting Around the Sun would make a Spacecraft the Fastest Ever

Top: Image of the test set-up for the thermal shield.
Credit – Benkoski et al.
Bottom: Graphic depicting the development path for the solar thermal propulsion system.
Credit – Benkoski et al.

NASA is very interested in developing a propulsion method to allow spacecraft to go faster. We’ve reported several times on different ideas to support that goal, and most of the more successful have utilized the sun’s gravity well, typically by slingshotting around it, as is commonly done with Jupiter currently.

But, there are still significant hurdles when doing so, not the least of which is the energy radiating from the sun simply vaporizing anything that gets close enough to utilize a gravity assist...

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Growth Factors linked to Stem Cell Aging in Bone Marrow Study

How old is your bone marrow?

The immunofluorescence image details the morphology and cell composition of a femur from a middle-aged mouse. Credit: The Jackson Laboratory

Our bone marrow—the fatty, jelly-like substance inside our bones—is an unseen powerhouse quietly producing 500 billion new blood cells every day. That process is driven by hematopoietic stem cells that generate all of the various types of blood cells in our bodies and regenerating themselves to keep the entire assembly line of blood production operating smoothly.

As with any complex system, hematopoietic stem cells lose functionality as they age—and, in the process, contribute to the risk of serious diseases, including blood cancers. We know that the risk of developing aging-associated diseases is different among different individuals...

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