Ointment containing DNA Molecules can Combat Allergic Contact Dermatitis

Ointment containing DNA molecules can combat allergic contact dermatitis
Fluorescence microscopic imaging of the skin treated with the aptamer cream: – The aptamers (here marked in pink) were applied to the top layer of the skin in the form of an ointment and also penetrate into the deeper dermal layers (nucleus: blue; antigen-presenting cells: green). Credit: Marlene Gottschalk

Researchers at the University of Bonn have isolated a DNA molecule that is suitable for combating allergic contact dermatitis in mice. The aptamer binds to certain immune system messenger substances, rendering them ineffective. This even works if the active ingredient is applied to the skin in the form of an ointment.

The working groups involved hope that aptamer creams such as this could also be suitable for treating other skin conditions...

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A New Brain-Inspired Artificial Dendritic Neural Circuit

Researchers at Tsinghua University recently introduced a new neuromorphic computational architecture designed to replicate the organization of synapses (i.e., connections between neurons) and the tree-like structure of dendrites (i.e., projections extending from the body of neurons).Read More

Webb admires Bejeweled Ring of the Lensed Quasar RX J1131-1231

Webb admires bejewelled ring
CREDIT: ESA/Webb, NASA & CSA, A. Nierenberg
LICENCE: CC BY 4.0 INT or ESA Standard Licence

This new picture of the month from the NASA/ESA/CSA James Webb Space Telescope features the gravitational lensing of the quasar known as RX J1131-1231, located roughly six billion light-years from Earth in the constellation Crater.

It is considered one of the best lensed quasars discovered to date, as the foreground galaxy smears the image of the background quasar into a bright arc and creates four images of the object.

Gravitational lensing, first predicted by Einstein, offers a rare opportunity to study regions close to the black hole in distant quasars, by acting as a natural telescope and magnifying the light from these sources...

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Key Mechanisms identified for Regeneration of Neurons

neuron
Credit: Pixabay/CC0 Public Domain

Neurological disorders, such as trauma, stroke, epilepsy, and various neurodegenerative diseases, often lead to the permanent loss of neurons, causing significant impairments in brain function. Current treatment options are limited, primarily due to the challenge of replacing lost neurons.

Direct neuronal reprogramming, a complex procedure that involves changing the function of one type of cell into another, offers a promising strategy.

In cell culture and in living organisms, glial cells—the non-neuronal cells in the central nervous system—have been successfully transformed into functional neurons. However, the processes involved in this reprogramming are complex and require further understanding...

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