Fungus-fighting Protein could help Overcome Severe Autoimmune disease and Cancer

A 3D printed stencil of the DECTIN-1 protein. Photo: Tracey Nearmy/ANU
A 3D printed stencil of the DECTIN-1 protein. Photo: Tracey Nearmy/ANU

A protein in the immune system programmed to protect the body from fungal infections is also responsible for exacerbating the severity of certain autoimmune diseases such as irritable bowel disease (IBS), type 1 diabetes, eczema and other chronic disorders, new research from The Australian National University (ANU) has found.

The discovery could pave the way for new and more effective drugs, without the nasty side effects of existing treatments. In addition to helping to manage severe autoimmune conditions, the breakthrough could also help treat all types of cancer. The work has been published in Science Advances.

The scientists have discovered a previously unknown function of the protein, known as DECTIN-1, w...

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24/7 Solar Towers Could Double Energy Output

Design illustration of the TTSS, where a) is a 2-dimensional view

If you want to improve the output of solar energy systems, why not also run them at night? That’s the question researchers in Qatar and Jordan addressed as they successfully devised a system that promises to more than double energy output of current solar power stations.

By combining two concepts—a solar updraft system and a cooling downdraft structure—researchers designed a model that could generate 753 MWh of energy annually. That’s enough to power roughly 753 homes for about five weeks or 1,500 60-watt light bulbs nonstop for a year.

The origins of the system, referred to as Solar Tower Power Plant, go back to 1982 when Spanish engineers constructed a chimney-like tower with a mechanical turbine at its base...

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Stellar Winds Regulate Growth of Galaxies

The scientists were able to identify the morphology of galactic winds. In this figure, magnesium atom emissions have been used to trace galactic winds. The flow of matter occurs along the central axis perpendicular to the galactic disc.
© Yucheng Guo

Galactic winds enable the exchange of matter between galaxies and their surroundings. In this way, they limit the growth of galaxies, that is, their star formation rate...

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Knocking Out part of the Innate Immune System to Improve Cancer Therapy

Credit: CC0 Public Domain

Researchers at Shanghai Jiao Tong University School of Medicine, China, have discovered that shutting down part of the innate immune system increases anti-tumor activity.

In a paper, “Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12,” published in Science Immunology, the team details how exploring the role of mitochondrial antiviral signaling in tumor immunity uncovered unexpected insights into the relationship with immune responses and potential therapeutic implications.

Mitochondrial antiviral-signaling (MAVS) proteins are part of the innate immune system encoded by the nuclear genome found mainly on the mitochondrial outer membrane...

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