Uranus and Neptune are hiding something big beneath the blue

Uranus and Neptune may not be the icy worlds we’ve long imagined. A new Swiss-led study uses innovative hybrid modeling to reveal that these planets could just as easily be dominated by rock as by water-rich ices. The findings also help explain their bizarre, multi-poled magnetic fields and open the door to a wider range of possible interior structures. But major uncertainties remain, and only future space missions will The Solar System is commonly grouped by planetary composition: four rocky terrestrial planets (Mercury, Venus, Earth and Mars), two massive gas giants (Jupiter and Saturn), and a pair of ice giants (Uranus and Neptune)...

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Dietary restriction fuels T-cells with ketones, boosting their cancer-fighting stamina

T cell
Credit: Pixabay/CC0 Public Domain

Reducing calorie intake helps cancer-fighting immune cells do their jobs more effectively, reports a study by Van Andel Institute scientists and collaborators. The findings lay the groundwork for developing dietary strategies to boost the effects of a powerful class of cancer immunotherapies.

“Growing evidence suggests dietary restriction has anti-cancer effects but the ‘why and how’ are not well understood. Our new study reveals one way this relationship may work: by providing T cells, the soldiers of the immune system, with the right mix of nutrients to more effectively fight cancer,” said Russell Jones, Ph.D., chair of VAI’s Department of Metabolism and Nutritional Programming and corresponding author of the study.

“Additional research is need...

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NASA-JAXA XRISM finds elemental bounty in supernova remnant

Observations of the Cassiopeia A supernova remnant by the Resolve instrument aboard the NASA-JAXA XRISM (X-ray Imaging and Spectroscopy Mission) spacecraft revealed strong evidence for potassium (green squares) in the southeast and northern parts of the remnant. Grids superposed on a multiwavelength image of the remnant represent the fields of view of two Resolve measurements made in December 2023. Each square represents one pixel of Resolve’s detector. Weaker evidence of potassium (yellow squares) in the west suggests that the original star may have had underlying asymmetries before it exploded.
NASA’s Goddard Space Flight Center; X-ray: NASA/CXC/SAO; Optical: NASA/ESA/STScI; IR: NASA/ESA/CSA/STScI/Milisavljevic et al., NASA/JPL/CalTech; Image Processing: NASA/CXC/SAO/J. Schmidt and K...
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‘Ready-made’ T-cell gene therapy tackles ‘incurable’ T-cell leukemia

CRISPR
Credit: Unsplash/CC0 Public Domain

A new treatment using genome-edited immune cells, developed by scientists at UCL (University College London) and Great Ormond Street Hospital (GOSH), has shown promising results in helping children and adults fight a rare and aggressive form of blood cancer called T-cell acute lymphoblastic leukemia (T-ALL).

The world-first gene therapy (BE-CAR7) uses base-edited immune cells to treat previously untreatable T-cell leukemia and help patients achieve remission, offering new hope for families facing this aggressive cancer. Base-editing is an advanced version of CRISPR technology, that can precisely change single letters of DNA code inside living cells.

In 2022, researchers from GOSH and UCL delivered the world’s first treatment made using “base-edi...

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