A UCLA-led team has identified an essential internal control mechanism that can promote the maturation of human stem cell-derived heart muscle cells, offering a deeper understanding of how heart muscle cells develop from their immature fetal stage to their mature adult form.

The findings, published in the journal Circulation, could lead to new therapies for heart disease and cardiac damage.

The collaborative effort with Duke-NUS Medical School in Singapore and other institutions identified an RNA splicing regulator named RBFox1, which was considerably more prevalent in adult heart cells than in newborns, based on a preclinical model. The sharp rise in RBFox1 during the maturation of heart cells was also confirmed through analyses of existing single-cell data.

“This is the fir...

Ever since Antonie van Leeuwenhoek discovered the world of bacteria through a microscope in the late seventeenth century, humans have tried to look deeper into the world of the infinitesimally small.

There are, however, physical limits to how closely we can examine an object using traditional optical methods. This is known as the diffraction limit and is determined by the fact that light manifests as a wave...

When stars are born, they do it inside a molecular cloud. Astronomers long assumed that the “crèche” supplied all the nutrients that protostars needed to form. However, it turns out they get help from outside the nest.

A new study published in the journal Astronomy & Astrophysics by scientists at the Max Planck Institute for Extraterrestrial Physics delved into the role of streamers and filaments in the star-birth process. Think of them as channels that extend out from the interior of the stellar creche, sometimes out as far as 10,000 astronomical units (about 0.15 light-years)...

Infections with cytomegalovirus (CMV) are extremely common and often pose no major threat to the vast majority of people. They can however be deadly for people whose immune system is weakened, e.g., after bone marrow transplantation. Current treatments against CMV infections are very limited and can have severe side effects. Researchers led by Prof...