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    Research demonstrates that Killer T cells can support Tissue Regeneration

    January 17, 2024, Categories  Health/Medical, Biology/Biotechnology

    Killer T cells support tissue regeneration
    Wound healing and target killing are both effector mechanisms of CD8 T cells. (A) Combined proliferation and killing assay in the presence of influenza-specific CD8 T cells and varying amounts of pulsed peptides on MRC-5 and HaCaT cells seeded in a 30:70 ratio. Left, representative image with labels (0 versus 5 h; T cells only versus T cells + 100 ng/ml peptide). Right, representative quantification of Cas3/7 activity (green) and HaCaT proliferation (red) with titrated amounts of influenza peptide, with statistical verification across experiments using normalized area under the curve (AUC, n = 3, one-way ANOVA, symbols indicate individual experiments). Scale bars = 400 µm; enhanced for improved visibility...
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    Team develops a new Deepfake Detector designed to be Less Biased

    January 17, 2024, Categories  Physics

    Study: New deepfake detector designed to be less biased
    Deepfake detection algorithms often perform differently across races and genders, including a higher false positive rate on Black men than on white women. New algorithms developed at the University at Buffalo are designed to reduce such gaps. Credit: Siwei Lyu

    University at Buffalo computer scientist and deepfake expert Siwei Lyu created a photo collage out of the hundreds of faces that his detection algorithms had incorrectly classified as fake—and the new composition clearly had a predominantly) darker skin tone.

    “A detection algorithm’s accuracy should be statistically independent from factors like race,” Lyu says, “but obviously many existing algorithms, including our own, inherit a bias.”

    Lyu, Ph.D...

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    ALMA Observations show how Double, Triple, Quadruple and Quintuple Star Systems Form Simultaneously in a Molecular Cloud

    January 17, 2024, Categories  Astronomy/Space

    Blue-green-yellow splashes of colour with red-white islands against a blue background.
    False-color image of the massive star formation region G333.23–0.06 from data obtained with the ALMA radio observatory. North is to the left. The insets show regions in which Li et al. were able to detect multiple systems of protostars. The star symbols indicate the location of each newly forming stars. The image covers a region 0.62 by 0.78 light-years in size (which on the sky covers a mere 7.5 times 9.5 arc seconds). For comparison: If you look at the sky along an outstretched thumb, it spans a viewing angle of around two degrees. One degree corresponds to 3600 arc seconds.
    © S. Li, MPIA / J. Neidel, MPIA Graphics Department / Data: ALMA Observatory

    For humans, the chance of giving birth to multiples is less than 2%...

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    Novel Regulator of Immune Evasion in Cancer identified

    January 16, 2024, Categories  Health/Medical, Biology/Biotechnology

    Novel regulator of immune evasion in cancer identified
    Representative images from immunohistochemical staining of PD-L1, ATXN3, IRF1, and HIF-2α in human lung adenocarcinoma (LUAD) and melanoma patients. Courtesy of Deyu Fang, PhD. Credit: Journal of Clinical Investigation (2023). DOI: 10.1172/JCI167728

    Northwestern Medicine investigators have identified a previously unknown regulator of tumor immune evasion, which may help improve the efficacy of current and future antitumor immunotherapies, according to recent findings published in the Journal of Clinical Investigation.

    “The study provides a molecular insight into understanding why some cancer patients cannot be treated by the checkpoint blockade antitumor therapy, but others can,” said Deyu Fang, Ph.D...

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