Exercise-induced Hormone Irisin may Reduce Alzheimer’s Disease Plaque and Tangle Pathology in the Brain

Reconstitution of amyloid plaques and NFT pathlogy. (Dooyeon Kim/Massachusetts General Hospital)

Medical researchers have used a 3D human neural cell culture model to show that the exercise-induced muscle hormone, irisin, reduces the level of amyloid beta deposits associated with Alzheimer’s disease.

Researchers who previously developed the first 3D human cell culture models of Alzheimer’s disease (AD) that displays two major hallmarks of the condition — the generation of amyloid beta deposits followed by tau tangles — have now used their model to investigate whether the exercise-induced muscle hormone irisin affects amyloid beta pathology.

As reported in the journal Neuron, the Massachusetts General Hospital (MGH)-led team has uncovered promising results suggesting that irisin-b...

Read More

New Cosmological Constraints on the Nature of Dark Matter

Dark matter fluctuations in the lens system MG J0414+0534. The whitish blue color represents the gravitationally lensed images observed by ALMA. The calculated distribution of dark matter is shown in orange; brighter regions indicate higher concentrations of dark matter and dark orange regions indicate lower concentrations. (Credit: ALMA (ESO/NAOJ/NRAO), K. T. Inoue et al.)

New research has revealed the distribution of dark matter in never before seen detail, down to a scale of 30,000 light-years. The observed distribution fluctuations provide better constraints on the nature of dark matter.

Mysterious dark matter accounts for most of the matter in the Universe. Dark matter is invisible and makes itself know only through its gravitational effects...

Read More

New Material offers more Durable, Sustainable Multi-level Non-volatile Phase Change Memory

Schematics of electrical resistivity switching and reentrant thermal in Sr2.5Bi0.5NiO5. The top two figures are the crystal structures of Sr2.5Bi0.5NiO5 with different Sr/Bi arrangements. The bottom figure is the crystal structure of double perovskite Sr2BiNiO4.5. The Blue value denotes electrical resistivity of each nickel. Â©Hideyuki Kawasoko et al.

Scientists have achieved a breakthrough in the development of non-volatile phase change memory −a type of electronic memory that can store data even when the power is turned off−−in a material that has never displayed the sort of characteristics that such memory requires.

Until now, phase change memory has primarily been developed using chalcogenides − a group of materials known to exhibit reversible electrical changes when they ...

Read More

Hot Jupiter Blows its Top

The planet HAT-P-32b is losing so much of its atmospheric helium that the trailing gas tails are among the largest structures yet known any planet outside our solar system. Simulation ‘slice’ through the orbital plane approximating the HAT-P-32 A + b system. Credit: Zhang et al., Sci. Adv. 9, eadf8736 (2023).

A planet about 950 light years from Earth could be the Looney Tunes’ Yosemite Sam equivalent of planets, blowing its atmospheric ‘top’ in spectacular fashion.

The planet called HAT-P-32b is losing so much of its atmospheric helium that the trailing gas tails are among the largest structures yet known of an exoplanet, a planet outside our solar system, according to observations by astronomers.

Three-dimensional (3D) simulations on the Stampede2 supercomputer of the Texas ...

Read More