Researchers solve protein mystery

Figur 1, se bildetekst for mer informasjon
N-terminal acetylation by NatC shields proteins from degradation

Researchers have uncovered that proteins use a common chemical label as a shield to protect them from degradation, which in turn affects motility and aging. Proteins are key to all processes in our cells and understanding their functions and regulation is of major importance.

“For many years, we have known that nearly all human proteins are modified by a specific chemical group, but its functional impact has remained undefined,” says professor Thomas Arnesen at the Department of Biomedicine, University of Bergen.

He explains:

“One of the most common protein modifications in human cells is N-terminal acetylation, which is an addition of a small chemical group (acetyl) at the starting tip (N-terminus) of a protein...

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Deep Learning Speeds up Galactic Calculations

Four square images showing dark backgrounds with stars and galaxies
Divide and conquer. The upper images show a wide area of a galaxy being simulated. The time resolution is very low, in which each “step” of the simulation is around 100,000 years. The lower images show the specific area affected by a supernova explosion and have a finer time resolution where each step is under 10,000 years. These regions are combined with the more general simulation to improve the overall accuracy and efficiency of the simulation. ©2023 Hirashima et al., NASA/JPL-Caltech/ESO/R. Hunt/Hubble/L. Calçada CC-BY-ND

A new way to simulate supernovae may help shed light on our cosmic origins. Supernovae, exploding stars, play a critical role in the formation and evolution of galaxies...

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Data from NASA’s WISE used to preview Lucy Mission’s Asteroid Dinkinesh

Two artist’s concepts show the WISE spacecraft, left, in front of an image of the infrared sky it observed during its prime mission, and NASA’s Lucy mission, right, during its Nov. 1 encounter with asteroid Dinkinesh.
NASA/JPL-Caltech and NASA’s Goddard Space Flight Center

NASA’s Lucy mission will soon have its first asteroid encounter as the spacecraft travels through deep space en route to Jupiter’s orbit. But before the spacecraft passes 265 miles (425 kilometers) from the surface of the small asteroid Dinkinesh, researchers have used 13-year-old infrared data from NASA’s Wide-field Infrared Survey Explorer (WISE) to support the mission’s flyby...

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Researchers Uncover Mechanism for Treating Dangerous Liver Condition

Illustration Credit: Julien Tromeur

A study spearheaded by Oregon State University has shown why certain polyunsaturated fatty acids work to combat a dangerous liver condition, opening a new avenue of drug research for a disease that currently has no FDA-approved medications.

Scientists led by Oregon State’s Natalia Shulzhenko, Andrey Morgun and Donald Jump used a technique known as multi-omic network analysis to identify the mechanism through which dietary omega 3 supplements alleviated nonalcoholic steatohepatitis, usually abbreviated to NASH.

The mechanism involves betacellulin, a protein growth factor that plays multiple positive roles in the body but also contributes to liver fibrosis, or scarring, and the progression to cirrhosis and liver cancer.

“We only succeeded in ...

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