Peptide from Venomous Fish Toxin Controls Lung Inflammation in Mice

Peptide from venomous fish toxin controls lung inflammation in mice
T. nattereri has four spines. It ejects venom through these spines when threatened by a predator, causing intense pain, swelling, and potentially necrosis. Credit: Mônica Lopes-Ferreira/CeTICS

A molecule found in the venomous toadfish Thalassophryne nattereri has proven capable of controlling lung inflammation and could be the basis for a more effective asthma drug. The research was conducted by scientists at Butantan Institute in São Paulo, Brazil. An article describing the results is published in the journal Cells.

A welter of fish species live in freshwater, seawater, and a mixture of the two, and some of them are venomous. They have spines or stingers connected to venom glands, which are a kind of pouch full of molecules, large and small, that are toxins...

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Meta’s AI MusicGen makes Music from Text Prompts

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Credit: Unsplash/CC0 Public Domain

The 19th century philosopher Thomas Carlyle once declared, “Music is well said to be the speech of angels.”

One wonders what Tom would have thought about a later era serving up protopunk, death metal and gothic rock.

Moreover, what would he have had to say about current approaches to music composed not by angels but by CPUs, RAM and large language models?

Meta announced last week that it has developed an AI music processor that generates music based on natural language descriptions.

Meta’s MusicGen, which follows on the heels of Google’s January release of MusicLM that generates music based on text prompts or humming, was trained on 20,000 hours of music...

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Pass the salt: This Space Rock holds clues as to how Earth got its Water

Asteroid Itokawa as seen by the Hayabusa spacecraft
Asteroid Itokawa as seen by the Hayabusa spacecraft. The peanut-shaped S-type asteroid measures approximately 1,100 feet in diameter and completes one rotation every 12 hours.JAXA

The discovery of tiny salt grains in a sample from an asteroid provides strong evidence that liquid water may be more common in the solar system than previously thought. Sodium chloride, better known as table salt, isn’t exactly the type of mineral that captures the imagination of scientists. However, a smattering of tiny salt crystals discovered in a sample from an asteroid has researchers at the University of Arizona Lunar and Planetary Laboratory excited, because these crystals can only have formed in the presence of liquid water.

Even more intriguing, according to the research team, is the fact that th...

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A New Way to Develop Drugs Without Side Effects

A new way to activate G protein-coupled receptors from inside the cell.

Have you ever wondered how drugs reach their targets and achieve their function within our bodies? If a drug molecule or a ligand is a message, an inbox is typically a receptor in the cell membrane. One such receptor involved in relaying molecular signals is a G protein-coupled receptor (GPCR). About one-third of existing drugs work by controlling the activation of this protein. Japanese researchers now reveal a new way of activating GPCR by triggering shape changes in the intracellular region of the receptor. This new process can help researchers design drugs with fewer or no side effects.

If the cell membrane is like an Oreo cookie sandwich, GPCR is like a snake with seven segments traversing in and out of the...

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