Human lifespan is related to the aging of our individual cells. Three years ago a group of University of California San Diego researchers deciphered essential mechanisms behind the aging process. After identifying two distinct directions that cells follow during aging, the researchers genetically manipulated these processes to extend the lifespan of cells.

As described in a new article published April 27, 2023, in Science, the team has now extended this research using synthetic biology to engineer a solution that keeps cells from reaching their normal levels of deterioration associated with aging.

Cells, including those of yeast, plants, animals and humans, all contain gene regu...

Emerging AI applications, like chatbots that generate natural human language, demand denser, more powerful computer chips. But semiconductor chips are traditionally made with bulk materials, which are boxy 3D structures, so stacking multiple layers of transistors to create denser integrations is very difficult.

However, semiconductor transistors made from ultrathin 2D materials, each only about three atoms in thickness, could be stacked up to create more powerful chips...

Elusive intermediate-mass black holes take a few bites, then eject the leftovers

In new 3D computer simulations, astrophysicists modeled black holes of varying masses and then hurled stars (about the size of our sun) past them to see what might happen. If they exist, intermediate-mass black holes likely devour wayward stars like a messy toddler — taking a few bites and then flinging the remains across the galaxy.

When a star approaches an intermediate-mass black hole, it initially gets caught in the black hole’s orbit, the researchers discovered. After that, the black hole begins its lengthy and violent meal. Every time the star makes a lap, the black hole takes a bite — further cannibalizing the star with each passage...

An international team of medical researchers has found a link between major depressive disorder (MDD) and an interplay between the gut microbiome and the blood metabolome. For their study, reported in the journal JAMA Psychiatry, the group analyzed data in the UK Biobank.

Some prior research has suggested there may be a link between MDD and conditions surrounding the gut biome, but little work has been done to prove a connection, and existing studies were too small to show any true connections. In this new effort, the researchers attempted to conduct a far more broad study of any such connections by studying data in the UK Biobank—a massive database of health and genetic information for nearly a half-million patients in the U.K.

The researchers...