New Small Laser Device can help Detect Signs of Life on other Planets

Photo of the Orbitrap mass analyzer from the prototype instrument. Photo courtesy of Lori Willhite and Ricardo Arevalo.

Mini-analyzer may revolutionize how astrobiology discoveries are made on faraway moons and planets. As space missions delve deeper into the outer solar system, the need for more compact, resource-conserving and accurate analytical tools has become increasingly critical — especially as the hunt for extraterrestrial life and habitable planets or moons continues.

A University of Maryland-led team developed a new instrument specifically tailored to the needs of NASA space missions...

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Modified CRISPR-based Enzymes improve the prospect of Inserting Entire Genes into the Genome to Overcome Diverse Disease-causing Mutations

Modified CRISPR-Based Enzymes Improve the Prospect of Inserting Entire Genes into the Genome to Overcome Diverse Disease-Causing Mutations
Noah Brownnbrown9@mgh.harvard.edu617-643-3907

Many genetic diseases are caused by diverse mutations spread across an entire gene, and designing genome editing approaches for each patient’s mutation would be impractical and costly.

Investigators at Massachusetts General Hospital (MGH) recently developed an optimized method that improves the accuracy of inserting large DNA segments into a genome.

This approach could be used to insert a whole normal or “wild-type” replacement gene, which could act as a blanket therapy for a disease irrespective of a patient’s particular mutation.

The work involves the optimization of a new class of technologies...

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How to Rewind the Clock on Arthritic Cartilage

knee cartilage
Credit: CC0 Public Domain

A new study in Aging Cell describes how a key protein called Signal Transducer and Activator of Transcription 3 (STAT3) might turn back the clock on aging cartilage that leads to osteoarthritis.

“STAT3 performs an astonishing repertoire of roles in development and regeneration, as well as inflammatory disease and cancer. In this study, we found an innovative chemical approach for reversing aging of joint-forming cells in a clinically relevant manner, because this intervention is simple and fully controlled,” said the study’s co-corresponding author Denis Evseenko, who is a Professor of Orthopaedic Surgery, and Stem Cell Biology and Regenerative Medicine at USC, and holds the J. Harold and Edna LaBriola Chair in Genetic Orthopedic Research.

“We wanted to ...

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Chance Discovery could Extend Battery Life by Replacing Tape that Causes Self‑discharge

Chance discovery could extend battery life by replacing tape that causes self‑discharge
Commercial battery cells contain tape—like Scotch tape—that holds electrodes together and chemical decomposition of it creates a molecule leading to self-discharge. Credit: Bram Van Oost/Unsplash

It happens far too often: you plug your laptop in and walk away only to return hours or days later to find it has lost some of its charge despite sitting idle and unused.

The phenomenon—called self-discharge—has frustrated users and industry alike, and puzzled manufacturers trying to determine why lithium-ion battery cells tend to lose some of their charge over time.

A researcher at Dalhousie has identified a surprisingly common culprit that, if replaced, could address an enduring problem for the industry.

“In commercial battery cells there is tape—like Scotch tape—that holds ...

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