New Intracellular ‘Smoke Detector’ discovered

Human skin cells with "healthy" mitochondria (light blue):
Human skin cells with “healthy” mitochondria (light blue): – The NLRP10 “smoke detector” (yellow-green) is distributed over the entire contents of the cell, apart from the nucleus (blue-violet).© Image: Kim S. Robinson/Skin Research Institute Singapore

Researchers at the Universities of Bonn and Singapore have discovered a new intracellular “smoke detector.” The sensor warns of damage to the mitochondria. If it does not function properly, chronic skin diseases can result. The sensor may also be important for unimpaired heart and bowel function. The results have now been published in the journal Nature Immunology.

Every cell in the body has numerous sensors that monitor its function...

Read More

RNA molecule Uracil found in Asteroid Ryugu Samples

A conceptual image for sampling materials on the asteroid Ryugu containing uracil and niacin by the Hayabusa2 spacecraft (NASA Goddard/JAXA/Dan Gallagher).
A conceptual image for sampling materials on the asteroid Ryugu containing uracil and niacin by the Hayabusa2 spacecraft (NASA Goddard/JAXA/Dan Gallagher).

Researchers have analyzed samples of the asteroid Ryugu collected by the Japanese Space Agency’s Hayabusa2 spacecraft and found uracil, one of the informational units that make up RNA, the molecules that contain the instructions for how to build and operate living organisms. Nicotinic acid, also known as Vitamin B3 or niacin, which is an important cofactor for metabolism in living organisms, was also detected in the same samples.

This discovery by an international team, led by Associate Professor Yasuhiro Oba at Hokkaido University, adds to the evidence that important building blocks for life are created in space and could have b...

Read More

UW Scientists use Tardigrade Proteins for Human Health breakthrough

man and woman working with lab equipment
UW student Maxwell Packebush, of Littleton, Colo., works with Silvia Sanchez-Martinez, a senior research scientist, to purify one of the tardigrade proteins used in a study showing that the proteins can be used to stabilize an important pharmaceutical for people with hemophilia and other conditions without the need for refrigeration. (Thomas Boothby Photo)

University of Wyoming researchers’ study of how microscopic creatures called tardigrades survive extreme conditions has led to a major breakthrough that could eventually make life-saving treatments available to people where refrigeration is not possible.

Thomas Boothby, an assistant professor of molecular biology, and colleagues have shown that natural and engineered versions of tardigrade proteins can be used to stabilize an impo...

Read More

Ultrafast Beam-steering Breakthrough

As a red beam of light is reflected in an arch, Prasad Iyer, right, and Igal Brener demonstrate optical hardware used for beam steering experiments at Sandia National Laboratories’ Center for Integrated Nanotechnologies. (Photo by Craig Fritz) Click on the thumbnail for a high-resolution image.

In a major breakthrough in the fields of nanophotonics and ultrafast optics, a Sandia National Laboratories research team has demonstrated the ability to dynamically steer light pulses from conventional, so-called incoherent light sources.

This ability to control light using a semiconductor device could allow low-power, relatively inexpensive sources like LEDs or flashlight bulbs to replace more powerful laser beams in new technologies such as holograms, remote sensing, self-driving cars an...

Read More