Telomeres, Mitochondria, and Inflammation oh my! Three hallmarks of Aging Work Together to Prevent Cancer

Telomeres protect the ends of chromosomes from damage. This image shows telomeres (green) and DNA (blue) during DNA repair activities.
Telomeres protect the ends of chromosomes from damage. This image shows telomeres (green) and DNA (blue) during DNA repair activities.

As we age, the end caps of our chromosomes, called telomeres, gradually shorten. Now, Salk scientists have discovered that when telomeres become very short, they communicate with mitochondria, the cell’s powerhouses. This communication triggers a complex set of signaling pathways and initiates an inflammatory response that destroys cells that could otherwise become cancerous.

The findings, published in Nature on February 8, 2023, could lead to new ways of preventing and treating cancer as well as designing better interventions to offset the harmful consequences of aging.

The discovery is the result of a collaboration between co-senior authors ...

Read More

Solar-Powered Gel Filters enough Clean Water to meet Daily Needs

Solar-powered gel filters enough clean water to meet daily needs
Researchers Néhémie Guillomaitre and Xiaohui Xu hold a sample of the solar absorber gel, which acts like a sponge to soak up clean water and filter out contaminants. Credit: Bumper DeJesus/Princeton University

Worldwide, over two billion people lack reliable access to clean water. And one potential solution for meeting that need works a lot like a sponge, soaking up clean water while leaving contaminants behind.

Researchers at Princeton University have developed the next generation of their solar absorber gel technology, a device that could be key to unlocking clean water access for people across the globe...

Read More

Footprints of Galactic Immigration uncovered in Andromeda Galaxy

A team of researchers led by astronomers at NSF’s NOIRLab has uncovered striking new evidence for a mass migration of stars into the Andromeda Galaxy. Intricate patterns in the motions of stars reveal an immigration history very similar to that of the Milky Way. The new results were obtained with the DOE’s Dark Energy Spectroscopic Instrument on the Nicholas U. Mayall 4-meter Telescope at Kitt Peak National Observatory, a Program of NSF’s NOIRLab.

The Dark Energy Spectroscopic Instrument reveals compelling evidence of a mass migration of stars into Andromeda Galaxy. Intricate patterns in the motions of stars reveal an immigration history very similar to that of the Milky Way.

Over the course of billions of years, galaxies grow and evolve by forging new stars and merging with o...

Read More

Wear and forget: An Ultrasoft Material for On Skin Health Devices

. Leakage-resistant property.
Conceptual illustration of conventional nonporous (A) and multifunctional porous (B) EGaIn composites upon compression. Here, porous structures can provide damping effect to substantially reduce stresses induced on liquid metal conductive pathways (see details in fig. S5), therefore endowing leakage-resistant property. In addition, antimicrobial additive can offer antibacterial and antiviral property. (C) Chemical structure of the antimicrobial additive, ε-PL, modified with BEHS for uniform dispersion in solvents. (D) Schematic of the EGaIn particle made by tip sonication of bulk EGaIn. (E) 3D tomography image of porous composites before sintering, showing EGaIn particle (yellow) distributions in elastomers (pink). Scale bar, 100 μm. (F) Photographs of compr...
Read More