Gut bacteria’s hidden toxin acts as DNA glue, fueling colorectal cancer risk

Discovery of how a gut toxin damages DNA gives scientists new clues to fight colorectal cancer
Structure and specificity of the colibactin-DNA interstrand cross-link. Credit: Science (2025). DOI: 10.1126/science.ady3571

Colibactin is a powerful toxin produced by Escherichia coli and other bacteria living in the human gut. This highly unstable bacterial product causes mutations in DNA that have been linked to colorectal cancer. Because it breaks down quickly, isolating and studying it has been difficult, but now scientists in the U.S. have discovered exactly how colibactin attacks DNA.

Using advanced tools such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy, the team studied the toxin at the atomic level, as reported in a paper published in the journal Science...

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Close-up images show how stars explode in real time

Astronomers have captured images of two stellar explosions—known as novae—within days of their eruption and in unprecedented detail. The breakthrough provides direct evidence that these explosions are more complex than previously thought, with multiple outflows of material and, in some cases, dramatic delays in the ejection process.

The international study, published in the journal Nature Astronomy, used a cutting-edge technique called interferometry at the Center for High Angular Resolution Astronomy (CHARA Array) in California. This approach allowed scientists to combine the light from multiple telescopes, achieving the sharp resolution needed to directly image the rapidly evolving explosions.

“The images give us a close-up view of how material is ejected away from the sta...

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Five ways microplastics may harm your brain

Five ways microplastics may harm your brain
MP’s ability to cross the BBB through phagocytosis and BBB damage Credit: Molecular and Cellular Biochemistry (2025). DOI: 10.1007/s11010-025-05428-3

Microplastics could be fueling neurodegenerative diseases like Alzheimer’s and Parkinson’s, with a new study highlighting five ways microplastics can trigger inflammation and damage in the brain.

More than 57 million people live with dementia, and cases of Alzheimer’s and Parkinson’s are projected to rise sharply. The possibility that microplastics could aggravate or accelerate these brain diseases is a major public health concern.

Pharmaceutical scientist Associate Professor Kamal Dua, from the University of Technology Sydney, said it is estimated that adults are consuming 250 grams of microplastics every year—enough to cover a...

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Number’s up: Calculators hold out against AI

In July, AI models made by Google, OpenAI and DeepSeek reached gold-level scores at the annual International Mathematical Olympiad
n July, AI models made by Google, OpenAI and DeepSeek reached gold-level scores at the annual International Mathematical Olympiad.

The humble pocket calculator may not be able to keep up with the mathematical capabilities of new technology, but it will never hallucinate.

The device’s enduring reliability equates to millions of sales each year for Japan’s Casio, which is even eyeing expansion in certain regions.

Despite lightning-speed advances in artificial intelligence, chatbots still sometimes stumble on basic addition.

In contrast, “calculators always give the correct answer,” Casio executive Tomoaki Sato told AFP.

But he conceded that calculators could one day go the way of the abacus.

“It’s undeniable that the market for personal calculators used in business is on a...

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