The viral replication cycle is crucial for a virus to spread inside the body and cause disease. Focusing on that cycle in the hepatitis A virus (HAV), UNC School of Medicine scientists discovered that replication requires specific interactions between the human protein ZCCHC14 and a group of enzymes called TENT4 poly(A) polymerases. They also found that the oral compound RG7834 stopped replication at a key step, making it impossible for the virus to infect liver cells.

These findings, published in the Proceedings of the National Academy of Sciences, are the first to demonstrate an effective drug treatment...

SCUBE3 identified as possible therapeutic treatment for androgenetic alopecia. University of California, Irvine-led researchers have discovered that a signaling molecule called SCUBE3 potently stimulates hair growth and may offer a therapeutic treatment for androgenetic alopecia, a common form of hair loss in both women and men.

The study, published online today in Developmental Cell, determined the precise mechanism by which the dermal papilla cells — speciali...

Today, exactly ten years after announcing the discovery of the Higgs boson, the international ATLAS and CMS collaborations at the Large Hadron Collider (LHC) report the results of their most comprehensive studies yet of the properties of this unique particle. The independent studies, described in two papers published today in Nature, show that the particle’s properties are remarkably consistent with those of the Higgs boson predicted by the Standard Model of particle physics...