How Mitochondrial Damage Ignites the ‘Auto-Inflammatory Fire’

A colorized transmission electron micrograph depicts cellular mitochondria with its characteristic internal folds called cristae.
A colorized transmission electron micrograph depicts cellular mitochondria with its characteristic internal folds called cristae. Thomas Deerinck, National Center for Microscopy and Imaging Research, UC San Diego.

Researchers describe the biochemical pathway that results in the generation of oxidized mitochondrial DNA, how it is expelled by mitochondria and how it triggers the complex and destructive inflammatory response that follows.

Mitochondria are self-contained organelles (they possess their own mini-chromosome and DNA) residing within cells and are charged with the job of generating the chemical energy needed to fuel functions essential to life and well-being.

When stressed, damaged or dysfunctional, mitochondria expel their DNA (mtDNA), oxidized and cleaved, into the cyto...

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Turning White Blood Cells into Medicinal Microrobots with Light

Two images of a neutrobot moving toward a nanoparticle
A laser precisely guided a “neutrobot” toward a nanoparticle (left image), which was picked up and transported away (right image).
Credit: Adapted from ACS Central Science 2022, DOI: 10.1021/acscentsci.2c00468

Medicinal microrobots could help physicians better treat and prevent diseases. But most of these devices are made with synthetic materials that trigger immune responses in vivo. Now, for the first time, researchers reporting in ACS Central Science have used lasers to precisely control neutrophils — a type of white blood cell — as a natural, biocompatible microrobot in living fish. The “neutrobots” performed multiple tasks, showing they could someday deliver drugs to precise locations in the body.

Microrobots currently in development for medical applications would require in...

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An Ocean of Galaxies Awaits

Photo of COMAP's radio dish
COMAP’s 10.4-meter “Leighton” radio dish at Owens Valley Radio Observatory.Credit: OVRO/Caltech

New COMAP radio survey will peer beneath the ‘tip of the iceberg’ of galaxies to unveil a hidden era of star formation. Sometime around 400 million years after the birth of our universe, the first stars began to form. The universe’s so-called dark ages came to an end and a new light-filled era began. More and more galaxies began to take shape and served as factories for churning out new stars, a process that reached a peak about 4 billion years after the Big Bang.

Luckily for astronomers, this bygone era can be observed. Distant light takes time to reach us, and our telescopes can pick up light emitted by galaxies and stars billions of years ago (our universe is 13.8 billion years old)...

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SFU researchers find the Missing Photonic Link to enable an All-Silicon Quantum Internet

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Researchers at Simon Fraser University have made a crucial breakthrough in the development of quantum technology.

Their research, published in Nature today, describes their observations of over 150,000 silicon ‘T centre’ photon-spin qubits, an important milestone that unlocks immediate opportunities to construct massively scalable quantum computers and the quantum internet that will connect them.

Quantum computing has enormous potential to provide computing power well beyond the capabilities of today’s supercomputers, which could enable advances in many other fields, including chemistry, materials science, medicine and cybersecurity.

In order to make this a reality, it is necessary to produce both stable, long-lived qubits that provide processing power, as well as the communi...

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