Signaling Molecule potently Stimulates Hair Growth

Hedgehog signaling in murine fibroblasts induces new hair growth and hair multiplication
•Hedgehog activation increases fibroblast heterogeneity and drives new cell states
•TGF-β pathway downstream of dermal Hedgehog mediates hair growth hyper-activation
•SCUBE3 is a new mesenchymal niche factor that activates hair growth

SCUBE3 identified as possible therapeutic treatment for androgenetic alopecia. University of California, Irvine-led researchers have discovered that a signaling molecule called SCUBE3 potently stimulates hair growth and may offer a therapeutic treatment for androgenetic alopecia, a common form of hair loss in both women and men.

The study, published online today in Developmental Cell, determined the precise mechanism by which the dermal papilla cells — speciali...

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A Ceramic Aerogel made with Nanocrystals and Embedded in a Matrix for use in Thermal Insulation Applications

A ceramic aerogel made with nanocrystals and embedded in a matrix for use in thermal insulation applications
Multiscale design of hypocrystalline ceramic nanofibrous aerogel. a, Deformation modes and the corresponding ν and α of crystalline (C), amorphous (A) and hypocrystalline (H) ceramic fibrous cells under mechanical and thermal excitations. The colored scale bar indicates the variation of ceramics from amorphous to crystal by using a local-entropy-based fingerprint to characterize the crystallinity of each atom in the simulated system. b, Illustration of the zig-zag architecture design based on hypocrystalline fibrous ceramics. The units of the colored scale bars are millimeters, presenting absolute displacement values in ν and α calculation. The triangle, square and pentagon cells are the building units to assemble the fibrous aerogel structure. Credit: Nature (2022). DOI: 10...
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ATLAS and CMS release results of most comprehensive studies yet of Higgs Boson’s properties

Atlas and CMS
From top to bottom, pictures of the ATLAS and CMS detectors (Image: CERN)

Today, exactly ten years after announcing the discovery of the Higgs boson, the international ATLAS and CMS collaborations at the Large Hadron Collider (LHC) report the results of their most comprehensive studies yet of the properties of this unique particle. The independent studies, described in two papers published today in Nature, show that the particle’s properties are remarkably consistent with those of the Higgs boson predicted by the Standard Model of particle physics...

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Breaking AIs to Make them Better

Grahical abstract explaining Raw-Zero-Shot
Image recognition AIs are powerful but inflexible and cannot recognize images unless they are trained on specific data. In Raw Zero-Shot Learning, researchers give these image recognition AIs a variety of data and observe the patterns in their answers. The research team hopes that this methodology can help improve the robustness of future AI. Illustrated by Hiroko Uchida.

Researchers investigate ways to make AIs more robust by studying patterns in their answers when faced with the unknown. Current AIs are very accurate but inflexible at image recognition. Exactly why this is remains a mystery. Researchers have developed a method called ‘Raw Zero-Shot’ to assess how neural networks handle elements unknown to them...

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