‘Molecular glue’ from this San Diego startup makes cancer self-destruct: Clinical trial begins

clinical trial
Credit: Unsplash/CC0 Public Domain

This local biotech says it has found a way to trick cancer cells into destroying themselves with its molecular glue. Now it’s putting that claim to the test. After attracting global attention from researchers and billions of dollars from Big Pharma, Neomorph announced that it has begun its first clinical trial. The molecular glue aims to treat a form of kidney cancer.

The first trial will dose one patient with the molecular glue, NEO-811, to treat clear cell renal cell carcinoma, the most common kind of kidney cancer.

In San Diego County, roughly 500 people are diagnosed with kidney cancer each year—that’s more than one new case every day, according to the California Cancer Registry...

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Is artificial general intelligence already here? A new case that today’s LLMs meet key tests

ai brain
Credit: Pixabay/CC0 Public Domain

Will artificial intelligence ever be able to reason, learn, and solve problems at levels comparable to humans? Experts at the University of California San Diego believe the answer is yes—and that such artificial general intelligence has already arrived. This debate is tackled by four faculty members spanning humanities, social sciences, and data science in a recently published Comment invited by Nature.

Computer scientist Alan Turing first posed this question in his landmark 1950 paper, though he didn’t use the term artificial general intelligence (AGI). His “imitation game,” now known as the Turing Test, asked whether a machine could pass as human in text-based conversation with humans. Seventy-five years later, that future is here.

Over the p...

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A giant star is changing before our eyes and astronomers are watching in real time

For decades, astronomers have been watching WOH G64, an enormous heavyweight star in the Large Magellanic Cloud, a galaxy visible with the naked eye from the Southern Hemisphere. This star is more than 1,500 times larger than the sun and emitting over 100,000 times more energy. For a long time, red supergiant WOH G64 looked like a star steadily reaching the end of its life, shedding material and swelling in size as it began to run out of fuel.

Astronomers didn’t think its final demise would happen anytime soon, because no one has ever seen a known red supergiant die. But in recent years, astronomers—including our team working with the Southern African Large Telescope (SALT)—discovered that this star has started to change, growing dimmer than before and seemingly warmer...

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Genetic study shows that anxiety disorders have many causes

Genetic study shows: Anxiety disorders have many causes
Manhattan plot of the main ANX GWAS showing 58 GWS loci. Credit: Nature Genetics (2026). DOI: 10.1038/s41588-025-02485-8

About 1 in 4 people suffer from an anxiety disorder at some point in their lives. These include panic disorder with sudden, severe anxiety attacks; generalized anxiety disorder, in which sufferers worry about everyday things over a longer period of time that is difficult to control; and phobias of specific objects or situations. Despite their widespread prevalence, the biological basis of anxiety is still poorly understood.

More light is now being shed on the subject by an international research team that has conducted the largest genetic study on anxiety disorders to date...

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