Specific Molecular Mechanism that controls the Transition from Acute to Chronic Pain

Daniele Piomelli
UCI School of Medicine
“This study is the first to identify that NAAA, a previously unrecognized control node, can be effectively targeted by small-molecule therapeutics that inhibit this enzyme, and block the transition from acute to chronic pain,” said Daniele Piomelli, PhD, Distinguished Professor in the UCI School of Medicine Department of Anatomy & Neurobiology.

Previously unrecognized control point identified as target for drugs that block transition. A new study led by University of California, Irvine researchers is the first to reveal the specific molecular mechanism that controls the transition from acute to chronic pain, and identifies this mechanism as a critical target for disease-modifying medicines.

Findings from the study, titled “NAAA-regulated lipid signaling gov...

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Topological Valley Hall Edge Solitons in Photonics

Experimental setup for observing nonlinear valley Hall edge states
Experimental setup for observing nonlinear valley Hall edge states. Credit: H. Zhong, S. Xia, et al., doi 10.1117/1.AP.3.5.056001

A novel topological edge soliton developed for nonlinear photorefractive lattices enables robust light beams is promising for photonic technology. Diffraction is a natural property of light beams. It allows light to bend around obstacles. Because light serves as a carrier of information, some of the distorting effects of diffraction must be mitigated for many technological applications. Topological insulators, first unveiled in condensed matter physics, have attracted interest for over a decade. A photonic topological insulator can help ensure consistent propagation of a light beam along its edges...

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Neutron Star Collisions are ‘Goldmine’ of Heavy Elements, study finds

Illustration shows two white cloud-like structures spiraling together to form a sphere circled by a ring of smaller gold particles

Mergers between two neutron stars have produced more heavy elements in last 2.5 billion years than mergers between neutron stars and black holes. Most elements lighter than iron are forged in the cores of stars. A star’s white-hot center fuels the fusion of protons, squeezing them together to build progressively heavier elements. But beyond iron, scientists have puzzled over what could give rise to gold, platinum, and the rest of the universe’s heavy elements, whose formation requires more energy than a star can muster.

A new study by researchers at MIT and the University of New Hampshire finds that of two long-suspected sources of heavy metals, one is more of a goldmine than the other.

The study, published today in Astrophysical Journal Letters, reports that in the last 2...

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Increased Consumption of Whole Grains could significantly Reduce the Economic Impact of Type 2 Diabetes

Increased consumption of whole grain foods could significantly reduce the incidence of type 2 diabetes and the costs associated with its treatment in Finland, according to a recent study by the University of Eastern Finland and the Finnish Institute for Health and Welfare. The findings were published in Nutrients.

“Our study shows that already one serving of full grains as part of the daily diet reduces the incidence of type 2 diabetes at the population level and, consequently, the direct diabetes-related costs, when compared to people who do not eat whole grain foods on a daily basis. Over the next ten years, society’s potential to achieve cost savings would be from 300 million (-3.3%) to almost one billion (-12...

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