First immune stimulating long noncoding RNA involved in body’s response to cancer

cancer cell in orange under microscope
Illustration of a T cell attacking a cancer cell. Roger Harris/Science Photo Library via Getty Images.

A long noncoding RNA whose function was previously unknown turns out to play an important role in promoting the body’s immune response against cancer and holds promise for enhancing the efficacy of anti-cancer immunotherapy.

That’s according to new findings reported in Nature Cell Biology by researchers at the University of Michigan Rogel Cancer Center.

The group dubbed the RNA they identified LIMIT—for long noncoding RNA inducing major histocompatibility complex class I and immunogenicity of tumor.

“LIMIT is easy to remember, but really it does the opposite. It stimulates immune functions against cancer,” says senior study author Weiping Zou, M.D., Ph.D., the Charles B...

Read More

Researchers Create New Zinc-Air Pouch Cells

Researchers create new zinc-air pouch cells
Credit: Shinde et al

Zinc-air batteries (ZABs) are among the most promising next-generation battery technologies due to their many advantageous characteristics. Most notably, these batteries have unique half-open structures, a significant theoretical energy density (1,086 and 1,370 Wh kg−1 when including and excluding oxygen, respectively), flexible electrodes and an inherently aqueous electrolyte. Moreover, in contrast with other materials used in batteries, Zinc (Zn) is less harmful for the environment and more abundant.

Researchers at Hanyang University in South Korea recently designed a new type of zinc-air pouch cell that can outperform other commercially available battery technologies...

Read More

Supermassive Black Holes Devour Gas just like their Petite Counterparts

black hole
As a supermassive black hole consumed a star, researchers were surprised it exhibited properties that were similar to that of much smaller, stellar-mass black holes.
Credits:Image: Christine Daniloff, MIT

On Sept. 9, 2018, astronomers spotted a flash from a galaxy 860 million light years away. The source was a supermassive black hole about 50 million times the mass of the sun. Normally quiet, the gravitational giant suddenly awoke to devour a passing star in a rare instance known as a tidal disruption event. As the stellar debris fell toward the black hole, it released an enormous amount of energy in the form of light.

Researchers at MIT, the European Southern Observatory, and elsewhere used multiple telescopes to keep watch on the event, labeled AT2018fyk...

Read More

A Long-lasting, Stable Solid-State Lithium Battery

The first electrolyte (green) is more stable with lithium but prone to dendrite penetration. The second electrolyte, (brown) is less stable with lithium but appears immune to dendrites. In this design, dendrites are allowed to grow through the graphite and first electrolyte but are stopped when they reach the second. (Image courtesy of Second Bay Studios/Harvard SEAS)
 

Researchers demonstrate a solution to a 40-year problem. A stable, lithium-metal solid state battery has been designed that can be charged and discharged at least 10000X — far more cycles than have been previously demonstrated — at a high current density. The battery technology could increase the lifetime of electric vehicles to that of the gasoline cars — 10 to 15 years — without the need to replace the battery...

Read More