(a) Schematic representation of HPSE biogenesis and the coexpression strategy used in this study. (b) Front view of apo-HPSE in ribbon representation. Subunits are colored yellow (8 kDa) and blue (50 kDa). Five sites of N-glycosylation are shown in green. (c) Side view of HPSE showing a binding cleft in the (β/α)8 domain in which the catalytic residues (green) reside.
Human heparanase, a sugar-degrading enzyme has received significant attention as a key target in anti-cancer treatments. Though naturally regulated in a healthy organism, heparanase is an enzyme which is produced in excessive quantities in a cancer situation...
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