This is a picture of Seborrheic keratosis lesions on a patient’s back. Credit: James Heilman, MD, via Wikimedia Commons
An investigation into the molecular mechanisms responsible for the most common type of benign skin lesion may lead to the first nonsurgical treatment for the growths, seborrheic keratoses (SKs), which in addition to being cosmetically unattractive are often worrisome to patients. Blocking a specific signaling enzyme Akt leads to the death of cultured SK cells and the breakdown of SK lesions with no effect on normal skin cells.
Sometimes called “senile warts,” “barnacles” or “liver spots,” SKs vary in color from tan to black, can be flat or raised, and range in size from quite small to an inch or more across...
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