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    aging tagged posts

    Longevity-promoting Superstar gets revealed in Caenorhabditis Reproducibility Project

    February 22, 2017, Categories  Biology/Biotechnology, Health/Medical

    (a–c) Dose response effects on the median lifespan of select C. briggsae strains after treatment with chemicals that exhibited strong positive effects on the C. elegans strains. Dosing was performed only on strains that failed to respond positively in the initial tests (single dose experiments), as we did not attempt to identify peak responses, instead we only sought to identify whether positive effects could be obtained by altering doses. Chemical doses were chosen to center around the effective dose identified for C. elegans strains and were sometimes expanded after preliminary rounds of testing. ThT exhibited a positive effect on strain JU1348 at 25 μM, but was profoundly toxic to all strains at and above 100 μM

    (a–c) Dose response effects on the median lifespan of select C. briggsae strains after treatment with chemicals that exhibited strong positive effects on the C. elegans strains. Dosing was performed only on strains that failed to respond positively in the initial tests (single dose experiments), as we did not attempt to identify peak responses, instead we only sought to identify whether positive effects could be obtained by altering doses. Chemical doses were chosen to center around the effective dose identified for C. elegans strains and were sometimes expanded after preliminary rounds of testing. ThT exhibited a positive effect on strain JU1348 at 25 μM, but was profoundly toxic to all strains at and above 100 μM

    The amyloid dye Thioflavin T emerged as the superstar when age rese...

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    Study finds Patterns of Biomarkers predict How Well people Age, Risks of Age-Related Disease

    January 7, 2017, Categories  Biology/Biotechnology, Health/Medical

    Paola Sebastiani, Bharat Thyagarajan, Fangui Sun, Nicole Schupf, Anne B. Newman, Monty Montano, Thomas T. Perls. Biomarker signatures of aging. Aging Cell, 2017; DOI: 10.1111/acel.12557

    Paola Sebastiani, Bharat Thyagarajan, Fangui Sun, Nicole Schupf, Anne B. Newman, Monty Montano, Thomas T. Perls. Biomarker signatures of aging. Aging Cell, 2017; DOI: 10.1111/acel.12557

    Levels of specific biomarkers can be combined to produce patterns that signify how well a person is aging and his or risk for future aging-related diseases, according to a new study by researchers at the Boston University Schools of Public Health and Medicine and Boston Medical Center. The study used biomarker data collected from the blood samples of almost 5,000 participants in the Long Life Family Study, funded by the National Institute on Aging (NIA) at the National Institutes of Health (NIH).

    A large number – about half – had an average “signature,” or pattern, of 19 biomarkers...

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    Cellular Reprogramming Slows Aging in Mice

    December 15, 2016, Categories  Biology/Biotechnology, Health/Medical

    Highlights •Partial reprogramming erases cellular markers of aging in mouse and human cells •Induction of OSKM in progeria mice ameliorates signs of aging and extends lifespan •In vivo reprogramming improves regeneration in 12-month-old wild-type mice

    Highlights •Partial reprogramming erases cellular markers of aging in mouse and human cells •Induction of OSKM in progeria mice ameliorates signs of aging and extends lifespan •In vivo reprogramming improves regeneration in 12-month-old wild-type mice

    In mice carrying a mutation leading to premature aging, reprogramming of chemical marks in the genome, ie epigenetic marks, reduced many signs of aging in the mice and extended their lifespan on average from 18 weeks to 24. The study suggests epigenetic changes drive the aging process, and that those changes may be malleable. “We did not correct the mutation that causes premature aging in these mice,” says Juan Carlos Izpisua Belmonte, a professor in the Salk Institute of Biological Science’s Gene Expression Laboratory...

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    Beneficial Effects of Exercise Change with Age

    June 8, 2016, Categories  Biology/Biotechnology, Health/Medical

    Exercise-induced ROS activates Nrf2, which then translocates into the nucleus to increase the expression of antioxidant enzymes. Antioxidant response element (ARE), carbon monoxide (CO), Glutathione peroxidase (GPx), Glutathione S-transferase (GST), Heme oxygenase-1 (HO-1), Kelch-like ECH-associated protein 1 (Keap1), NAD(P)H quinone oxidoreductase-1 (NQO-1), and nuclear factor erythroid 2-related factor 2 (Nrf2).

    Exercise-induced ROS activates Nrf2, which then translocates into the nucleus to increase the expression of antioxidant enzymes. Antioxidant response element (ARE), carbon monoxide (CO), Glutathione peroxidase (GPx), Glutathione S-transferase (GST), Heme oxygenase-1 (HO-1), Kelch-like ECH-associated protein 1 (Keap1), NAD(P)H quinone oxidoreductase-1 (NQO-1), and nuclear factor erythroid 2-related factor 2 (Nrf2).

    If you’re an older adult, a 30 min workout may not be as effective, even at the cellular level, as it was when you were younger. According to a new study, age may play a significant role in a cell’s ability to respond to that activity. In the study, a group of men 18 to 30 yo were tested against a group of older men 55 years and older...

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