The reddish-blue mouse neurons in this image have reentered the cell cycle after exposure to amyloid beta oligomers, and thus are primed for death.
Credit: Image by Erin Kodis and George Bloom
About 50% of people who reach the age of 85 will develop Alzheimer’s disease. Most will die within about 5 years of exhibiting the hallmark symptoms of the disease – severe memory loss and a precipitous decline in cognitive function. But the molecular processes that lead to the disease will have begun years earlier.
Currently, there are no known ways to prevent the disease or to stop its progression once it has begun. But research at the University of Virginia offers new understanding of how the disease develops at the molecular level, long before extensive neuronal damage occurs and symptoms show up.
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