CDK8 is asymmetrically loaded at SEs in MOLM-14 cells.
“Once we learned this molecule named cortistatin A was very potent and selective in terms of inhibiting the growth of AML cells, we tested it in mouse models of AML and found that it was as efficacious as any other molecule we had seen, without having deleterious effects,” Shair said. “This suggests we have identified a promising new therapeutic approach.” It’s one that could be available to test in patients relatively soon.
“We synthesized cortistatin A and we are working to develop novel therapeutics based on it by optimizing its drug-like properties,” Shair said.
MOA: The molecule inhibits a pair of nearly identical kinases, called CDK8 and CDK19, that his work indicates play a key role in the growth of AML cells...
Read More
Recent Comments