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Scientists Prevent, Reverse Diabetes-related Kidney Destruction in Animal

Scientists prevent, reverse diabetes-related kidney destruction in animal model

Dr. Ganesan Ramesh, Medical College of Georgia at Georgia Regents University. Credit: Augusta University Senior Photographer Phil Jones

Diabetes is the leading cause of kidney failure, and scientists have found that infusing just a small dose of a cytokine, thought to help cause that failure, can instead prevent or reverse it. The cytokine IL-17A has long been considered a classic promoter of inflammation, which plays a major role in progression of diabetes-related kidney disease, or diabetic nephropathy, said Dr. Ganesan Ramesh. His lab was pursuing its role in kidney damage but found that when they deleted the IL-17 gene in mice, then induced diabetes, it resulted in increased kidney injury...

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