amyloid beta (Aβ) tagged posts

A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer’s disease. The approach also reduced the toxicity of protein aggregates that had already formed.

In experiments using a mouse model of Alzheimer’s disease, the treatment reduced protein accumulation in the brain and improved memory recognition, suggesting a possible route toward new therapeutics.

The research team led by Professor Mi Hee Lim from the Department of Chemistry identified a new approach to controlling the aggregation and toxicity of amyloid-beta. The findings were published in Advanced Science.

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Advanced imaging technique shows how cholesterol regulates production of Alzheimer’s-associated amyloid beta protein in a type of brain cell.

A team co-led by scientists at Scripps Research has used advanced imaging methods to reveal how the production of the Alzheimer’s-associated protein amyloid beta (Aβ) in the brain is tightly regulated by cholesterol.

Appearing on line Thursday ahead of print in the Aug...